-
Te Whakamārama Whānui o te Whakaora Pūtau-T CAR
Ko te CAR-T (Chimeric Antigen Receptor T-Cell), arā, ko ngā pūtau-T receptor antigen chimeric, he tukanga e hangaia ai ngā pūtau-T o te tangata i roto i te ira i waho o te tinana kia whakarerekētia, kia taea ai e rātou te kite me te patu pai i ngā pūtau matepukupuku i mua i te whakaurunga anō ki roto i te tinana o te tūroro, ā, kia tutuki ai te whāinga o te rongoā i ngā pukupuku kino.
Ina hoki, ehara i te mea ko te rongoā mate pukupuku anake te mea e whakamahia ana mō te rongoā i ngā mate pūnaha ārai mate, ngā mate pūmau, ngā mate ngakau, me ngā mate e pā ana ki te koroheketanga.
Ko ngā pūtau-T, e mōhiotia ana ko ngā pūtau-T lymphocytes, ngā wāhanga matua o ngā pūtau-T lymphocytes, ā, ko rātou te kawenga matua mō ngā urupare ārai mate me te parenga mate. He mahi ā rātou pēnei i te patu tika i ngā pūtau ūnga, te āwhina me te aukati i ngā pūtau-B ki te whakaputa paturopi, te urupare ki ngā antigens me ngā mitogens motuhake, me te whakaputa cytokines.
Heoi anō, kāore te pūnaha ārai mate tangata e herea noa ki ngā pūtau-T; kei roto hoki i ēnei ko ngā pūtau-B, ngā neutrophils, ngā pūtau-K, ngā pūtau-NK, me ētahi atu. He mahi tā rātou ki te tango i ngā hua para o te pākia o te tinana, ki te mōhio me te whakaputa i ngā paturopi, me te tautuhi me te patu i ngā mate urutā me ngā pūtau matepukupuku ke.
I te mea kei ngā pūtau-T te mahi ki te kite me te patu i ngā pūtau matepukupuku, he aha i hiahiatia ai te tāpiri hangai i te CAR ki ngā pūtau-T hei hanga i ngā pūtau CAR-T hei patu i ngā pūtau matepukupuku? Nā tēnei ka tae mai tātou ki te ariā o te karo i te ārai mate, koinei tētahi o ngā āhuatanga tino taketake o te matepukupuku.
Ko te rongoā CAR-T, ko te rongoā pūtau CAR-T rānei, ko te wehewehe i ngā pūtau-T o te tūroro, te whakawhānui i a rātou ki waho o te tinana, kātahi ka whakauru i tētahi antigen pūtau pukupuku CAR (chimeric antigen receptor) i hangaia ā-hangai ki ngā pūtau-T. I muri i te tukatuka, ka tino whakanuia te mahi ārai-pukupuku o ngā lymphocytes T i mua i te whakaurunga anō ki roto i te tinana o te tūroro, ā, ka whakahokia mai te kaha o ngā pūtau-T ki te kite me te patu i ngā pūtau matepukupuku. Koinei te kaupapa matua o te rongoā pūtau CAR-T.
Kua whakaaetia e te FDA te rongoā CAR-T IMPT-514 a Impact Bio.
I te 21 o Ākuhata, 2024, i panuitia e Impact Bio kua whakaaetia e te FDA tana tono IND mō te rongoā IMPT-514 i whakawhanakehia e ia. Ko te IMPT-514 he rongoā CD19/CD20 CAR-T takirua e whakamahia ana hei rongoā i te lupus erythematosus pūnaha pakari (SLE) kaha. I roto i ngā raraunga whakamātautau haumanu, i whakaatuhia te tino whai huatanga o te IMPT-514 ki te whakaputa mai i ngā tūroro he nui te pehanga ārai mate mai i ngā mate pūnaha ārai mate, ā, i whakaatuhia e ia he kaha ki te whakakore i ngā pūtau-B autologous me te kōtaha cytokine ngawari. Kei te whakaatu tonu te rongoā Axicabtagene ciloleucel CAR-T mō te lymphoma pūtau-B nui i te urupare pumau i muri i ngā tau e rima. I te 2 o Ākuhata, 2024, i tukuna e te American Society of Clinical Oncology (ASCO) he pūrongo raraunga mō ngā reiti oranga roa i muri i te rongoā pūtau CAR-T. I whakaatuhia e ngā hua i roto i ngā tūroro i whiwhi i te rongoā CAR-T, ko te reiti oranga kore-whakahaere mō te 5 tau he 29%, ko te reiti oranga whānui (OS) mō te 5 tau he 40%, ā, ko te reiti oranga motuhake ki te lymphoma mō te 5 tau he 53%, me ngā hokinga whakamuri onge. Ko te Axicabtagene ciloleucel he rongoā pūtau CAR-T CD19 chimeric antigen receptor autologous kua whakaaetia mō te rongoā i te lymphoma pūtau-B nui kua hoki whakamuri, kua ātete rānei. Whakamutunga: I roto i te horopaki tiaki paerewa, ko ngā putanga maimoatanga o te axicabtagene ciloleucel CAR-T he rite ki ngā hua i pūrongohia i roto i ngā whakamātautau haumanu, me ngā urupare pumau, roa i kitea i te tohu tau 5.
Ko te maimoatanga CAR-T angitu tuatahi o te ao mō ngā mate pūnaha ārai mate.I te 4 o Oketopa, 2024, i puta te paetukutuku Nature hei upoko mō tētahi pūrongo e whakaatu ana i tētahi hua rangahau mai i tētahi tīma Hainamana. I whakamahia e ngā kaipūtaiao te hangarau whakatika ira CRISPR-Cas9 hei hanga ira i ngā pūtau CAR-T hauora i ahu mai i ngā kaituku e aro ana ki te CD19, me te whakawhanake i tētahi whakatupuranga hou o te rongoā CAR-T whānui allogeneic i āwhina i ētahi tūroro e toru me ngā mate pūnaha ārai mate kino kia tutuki ai te murunga roa.
-
Ngā raruraru hauora e pakaru ana i te "Cryoablation o te Pūkahukahu"
Ko te maimoatanga auau o ngā pona pūkahukahu ko te koiora me te pneumonectomy.
He ngāwari te puta o ngā raruraru pēnei i te pneumothorax me te hemothorax i te wā o te koiora.
He tūponotanga kei te marere ngā pūtau pukupuku me te horapa ki te tinana. He uaua ki te tautuhi i te mate nā te iti o te kiko e tangohia ana i te koiora o ia rā.
-
Matepukupuku pūkahukahu
Ko te mate pukupuku pūkahukahu (e mōhiotia ana ko te mate pukupuku pūkahukahu) he mate pukupuku pūkahukahu kino e puta mai ana i ngā kiko epithelial pūkahukahu o ngā momo rerekē. E ai ki te āhua, ka wehea ki waenganui, ki te taha, me te rahi (whakaranu).
-
Matepukupuku o te Ara Nakunaku
I te tīmatanga o te pukupuku o te ara kai, kāore he tohu mamae, kāore hoki he mamae e kitea ana, engari mā te tirotiro i te ara kai me te whakamātautau toto huna ka kitea ngā toto whero i roto i te tūtae, e tohu ana i te toto o te puku. Mā te gastroscopy ka kitea ngā rauropi hou e kitea ana i roto i te ara kai i te tīmatanga.
-
Matepukupuku Repeure
Ko te mate pukupuku repeure tetahi o ngā mate pukupuku tino whakamate e pā ana ki te repeure, he okana kei muri i te puku. Ka puta mai ina tīmata ngā pūtau rerekē o te repeure ki te tipu haere, ka hanga he pukupuku. Ko ngā wāhanga tōmua o te mate pukupuku repeure kāore e puta he tohu. I te tipu haere o te pukupuku, ka puta pea ngā tohu pēnei i te mamae o te puku, te mamae o te tuara, te ngaro o te taumaha, te ngaro o te hiahia kai, me te jaundice. Ka puta pea ēnei tohu i ētahi atu āhuatanga, nō reira he mea nui kia kite i te tākuta mēnā ka pāngia koe e tētahi o aua tohu.
-
Matepukupuku Prostate
He pukupuku kino noa te mate pukupuku repeure e kitea ana i te tipu me te horapa o ngā pūtau mate pukupuku repeure i roto i te tinana tāne, ā, ka piki ake tōna auau i te pakeketanga. Ahakoa he mea nui te tautuhi wawe me te maimoatanga, ka taea tonu e ētahi maimoatanga te āwhina i te whakaroa i te whanaketanga o te mate me te whakapai ake i te tere ora o ngā tūroro. Ka taea te puta te mate pukupuku repeure i ngā tau katoa, engari ko te nuinga o te wā ko te mea tino noa i roto i ngā tāne neke atu i te 60 tau te pakeke. Ko te nuinga o ngā tūroro mate pukupuku repeure he tāne, engari tera pea he wāhine me ngā takatāpui.
-
Matepukupuku o te ovarian
Ko te ovary tētahi o ngā okana whakaputa uri nui o roto o ngā wāhine, ā, koia hoki te okana ira tangata matua o ngā wāhine. Ko tāna mahi he whakaputa hua manu, he hanga me te whakaputa homoni. He nui te auau o te mate i waenga i ngā wāhine. He tino mōrearea ki te oranga me te hauora o ngā wāhine.
-
Matepukupuku whatukuhu
Ko te mate pukupuku pūtau whatukuhu he pukupuku kino e ahu mai ana i te pūnaha epithelial ngongo mimi o te parenchyma whatukuhu. Ko te kupu mātauranga ko te mate pukupuku pūtau whatukuhu, e mōhiotia ana ko te adenocarcinoma whatukuhu, e kiia ana ko te mate pukupuku pūtau whatukuhu. Kei roto i tēnei ko ngā momo momo mate pukupuku pūtau whatukuhu e ahu mai ana i ngā wāhanga rerekē o te ngongo mimi, engari kāore e uru ana ki ngā pukupuku e ahu mai ana i te interstitium whatukuhu me ngā pukupuku pelvis whatukuhu. I te tau 1883, i kite a Grawitz, he tohunga mate Tiamana,... -
Matepukupuku wheua
He aha te mate pukupuku wheua? He hanganga ahurei tēnei e mau ana i te anga, i te anga, i te angaanga tangata. Heoi, ahakoa tēnei pūnaha e ahua pakari ana, ka taea te waiho hei piringa mō ngā pukupuku kino. Ka taea e ngā pukupuku kino te whanake takitahi, ā, ka taea hoki te whakaputa mā te whakaora anō i ngā pukupuku pai. I te nuinga o te wā, ki te kōrero tātou mō te mate pukupuku wheua, ko te tikanga ko te mate pukupuku metastatic, ina whanake te pukupuku ki ētahi atu okana (pūkahukahu, ū, repeure) ā, ka horapa i te wā mutunga, tae atu ki te wheua ... -
Matepukupuku ate
He aha te mate pukupuku ate? Tuatahi, me ako tātou mō tētahi mate e kiia nei ko te mate pukupuku. I raro i ngā āhuatanga noa, ka tipu ngā pūtau, ka wehe, ka whakakapi i ngā pūtau tawhito kia mate. He tukanga pai tēnei me tētahi tikanga whakahaere mārama. I ētahi wā ka whakangaromia tēnei tukanga, ka tīmata ki te whakaputa i ngā pūtau kāore e hiahiatia ana e te tinana. Ko te mutunga iho, ka taea e te pukupuku te noho pai, te noho kino rānei. Ehara te pukupuku pai i te mate pukupuku. E kore e horapa ki ētahi atu okana o te tinana, e kore hoki e tupu anō i muri i te pokanga. Ahakoa... -
Te mate pukupuku o te repeure
Ko te Carcinomaofrectum e kiia ana ko te mate pukupuku colorectal, he pukupuku kino noa i roto i te ara kai, ko te tuarua anake o te mate pukupuku puku me te korokoro, koinei te wāhanga tino noa o te mate pukupuku colorectal (tata ki te 60%). Ko te nuinga o ngā tūroro he neke atu i te 40 tau te pakeke, ā, tata ki te 15% he iti iho i te 30 tau te pakeke. He nui ake te kitea o te tāne, ko te ōwehenga o te tāne ki te wahine he 2-3:1 e ai ki te tirohanga haumanu, kua kitea ko tetahi wāhanga o te mate pukupuku colorectal ka puta mai i ngā polyp rectal, i te schistosomiasis rānei; ko te mumura mau tonu o te whekau, ko ētahi ka taea te whakaoho i te mate pukupuku; ko te kai momona me te nui o te pūmua ka piki ake te whakaputanga o te waikawa cholic, ka pakaruhia te mea whakamutunga ki ngā hydrocarbons polycyclic kore-makuku e ngā anaerobes whekau, ka taea hoki te mate pukupuku.
-
Matepukupuku o te kōpū
Ko te mate pukupuku o te kōpū waha, e mōhiotia ana ko te mate pukupuku o te kōpū waha, te pukupuku wahine tino kitea i roto i te ara uri wahine. Ko te HPV te mea tino nui mō te mate. Ka taea te ārai i te mate pukupuku o te kōpū waha mā te tirotiro auau me te werohanga. Ka tino ora te mate pukupuku o te kōpū waha i te wā tōmua, ā, he pai te āhua o te putanga mai.
Te whare hauora mahi tahi o te Hōhipera Matepukupuku o Beijing