Nō nā tata nei, i kī te Center for Drug Assessment (CDE) o te National Medical Products Administration (NMPA) o Haina kua whakaaetia te Encorafenib kia arotakehia mō te wā poto. Ka whakamahia ngātahitia me te cetuximab me te tikanga rongoā FOLFOX hei rongoā tuatahi mō ngā tūroro pakeke e pangia ana e te mate pukupuku colorectal metastatic BRAF V600E-mutant.
He tohu tēnei i tētahi whanaketanga nui i roto i te hapori hauora o te ao mō tēnei mate pukupuku uaua ki te rongoā, e hua mai ana i tētahi whakarerekētanga ira motuhake.
**He aha te Encorafenib, ā, he aha te hiranga o tēnei?**
He tino whiriwhiri a Encorafenib, he aukati BRAF iti-ngota, he ATP-whakataetae. I roto i ngā kupu ngāwari, ka aro tika ki ngā pūtau pukupuku e mau ana i te whakarerekētanga BRAF V600E, ka aukati i tō rātou tipu me te horapa. Ki te whakatauritea ki ētahi aukati BRAF kua whakaaetia i mua, he roa ake te mahi pharmacodynamic a Encorafenib, ko te tikanga ka noho whai hua i roto i te tinana mō te wā roa ake.
**Ngā Raraunga Hauora: Ngā Taunakitanga o te Whai Huatanga Hou**
I te 25 o Hānuere, 2025, i whakaputaina e *Nature Medicine* te rangahau haumanu Wāhanga 3 o Encorafenib + Cetuximab + chemotherapy mō te rongoā i te mate pukupuku colorectal BRAF-mutant. Ko te whāinga o te rangahau BREAKWATER (NCT04607421) he aromatawai i te whai huatanga o te encorafenib me te cetuximab me te kore rānei he chemotherapy paerewa i roto i ngā tūroro he mate pukupuku colorectal BRAF V600E-mutant. E 236 ngā tūroro katoa i whakaritea matapōkeretia ki te rōpū whakamātautau me te 243 ki te rōpū whakahaere. I whakaatuhia e ngā hua he reiti urupare whāinga kua whakaūtia (cORR) o te 60.9% i roto i te rōpū whakamātautau, me te 3 ngā tūroro i tutuki i te urupare katoa (CR), 64 te urupare wāhanga (PR), me te 31 te mate pumau (SD). I roto i te rōpū whakahaere, ko te cORR he 40.0%, me te 2 CR, 42 PR, me te 34 SD. Ko te roanga waenga o te urupare (DOR) he 13.9 marama me te 11.1 marama, ia. Kāore i taea te whakatau tata i te oranga whānui mō te rōpū whakamātautau, ki te whakaritea ki te 14.6 marama i te rōpū whakahaere.
**Mō ngā Tūroro o Tāwāhi: Kei te Tari Ao o te Hōhipera Oncology Rohe o Beijing South te Huarahi ki te Maimoatanga Hou**
Kua uru atu tēnei tikanga maimoatanga matatau ki te ara arotake matua i Haina. Mō ngā tūroro o tāwāhi—mēnā kei te rapu koe, kei te rapu rānei tētahi mema o te whānau i ngā kōwhiringa maimoatanga pai ake—e whakapau kaha ana te Tari Ao o te Hōhipera Matepukupuku o te Rohe Tonga o Beijing ki te mahi hei piriti ki te hangarau hauora matatau o te ao. Ka whai tata mātou i ngā whanaketanga rongoā o te ao, ā, ka tuku kōrero ngaio me te āwhina hauora ki ngā tūroro e tika ana.
**Whakapā mai ki a mātou i tēnei rā hei tīmata i tō haerenga o te tumanako**
Kaua e tatari. Kei ia maimoatanga te kaha ki te whakarerekē i te huarahi o te oranga. Kei te rite tā mātou tīma ratonga reo maha ki te whakarato kōrero, whakarite wā, me te ārahi hauora.
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Ka taea e koe te whakapā mai ki a mātou mā tētahi o ngā hongere o runga ake nei. Ka tere te whakautu a ā mātou kaiwhakahaere tūroro o te ao ki te āwhina i te whakaritenga o ngā pūkete hauora, te aromatawai i ngā kōwhiringa maimoatanga, me ngā pātai katoa e pā ana ki te rapu tiaki i Beijing. Kei te rite tonu te Tari Ao o te Hōhipera Matepukupuku o te Rohe Tonga o Beijing ki te aro atu ki ngā wero me koe, me te ngaio me te aroha.
Wā tuku: Paenga-whāwhā-23-2026