I te 10 o Poutū-te-rangi, 2026, i whakawhiwhia te B7-H3-targeting antibody-drug conjugate (ADC) YL201 auaha mō te werohanga, i whakawhanakehia e MediLink Therapeutics, ki te Breakthrough Therapy Designation e te Center for Drug Evaluation of China's National Medical Products Administration. Ko te tohu kua tohua kei te taha o Serplulimab mō te maimoatanga tuatahi o te mate pukupuku pūkahukahu iti wāhanga whānui (ES-SCLC).
He ADC auaha a YL201 e aro ana ki te B7H3. He nui rawa te whakaputanga o te pūmua B7H3 ki ngā pūtau kino me ngā pūtau e tīmata ana i te mate pukupuku o ngā momo pukupuku rerekē, engari he iti noa te whakaputanga i roto i te kiko noa, e whakaatu ana i tōna pūmanawa hei whāinga rongoā ADC. I whakawhanakehia a YL201 mā te whakamahi i te hangarau Tumor Microenvironment Activable LINker-payload (TMALIN®) a MediLink e honoa ana ki te paturopi B7H3 tino motuhake. I tēnei wā, kei te tirotirohia a YL201 i roto i ngā momo pukupuku totoka, ā, kua uru ki ngā whakamātautau taumata-matua i roto i te Mate Pukupuku Pūtau Iti me te Mate Pukupuku Nasopharyngeal i Haina.
### Raraunga Hauora Mana: He Whai Huatanga Nui me te Haumaru Pai
I te marama o Poutū-te-rangi 2025, i whakaputa te hautaka taumata-nui o te ao *Nature Medicine* i ngā raraunga mai i te whakamātautau haumanu Wāhanga 1/1b o YL201 i roto i ngā tūroro he pukupuku totoka kua whanake. I whakaatuhia e tēnei rangahau, i uru atu ki te 312 ngā tūroro:
- **Te Whai Huatanga Whānui:** I roto i ngā tūroro 287 i arotakehia, ko te auau urupare whāinga (ORR) he mea whakamiharo, arā, 40.8%, tae atu ki te 2 o ngā tūroro i tutuki te urupare katoa (CR) me te 115 i tutuki te urupare wāhanga (PR). Ko te auau whakahaere mate (DCR) i eke ki te 83.6%.
- **Te Matepukupuku Pūtau Iti Wāhanga Whānui (ES-SCLC):** Mō ngā tūroro i rongoatia i mua ki te rongoā matū konupūmā, ko te ORR he 63.9%, ko te DCR he 91.7%, ā, ko te oranga kore-haere-ake toharite (mPFS) he 6.3 marama.
- **Te Mate Pukupuku Ihu (NPC):** I roto i ngā tūroro 70, ko te ORR he 48.6%, ko te DCR he 92.9%, ā, e rua ngā tūroro i tutuki te urupare katoa. Ko te roanga waenga o te urupare (mDOR) he 8.4 marama te roa.
E whakaū ana ēnei raraunga i te kaha o te mahi ārai-puku me te haumaru o te YL201 puta noa i ngā momo pukupuku totoka matatau, e whakatakoto ana i te turanga pakari mō ngā rangahau haumanu e whai ake nei me te tono whānui ake.
### Tari Ao o te Hōhipera Matepukupuku o te Rohe Tonga o Beijing: Tō Piriti ki te Rongoā o te Ao
Kei te whakapau kaha tonu te Tari Ao o te Hōhipera Matepukupuku o te Rohe Tonga o Beijing ki te whakauru i ngā hangarau me ngā rongoā matua o te ao mō te tātaritanga me te maimoatanga matepukupuku. E whai tata ana mātou i ngā ahunga whakamua o te rangahau hou, ā, e mau tonu ana te mahi tahi kaha me ngā umanga pūtaiao matua o te motu me te ao, me te whai kia wātea wawe ki ngā tūroro o te ao ngā kōwhiringa maimoatanga hou tae atu ki te YL201.
Ka taea e tā mātou tīma Ratonga Tūroro o te Ao te whakarato ki a koe:
- **Aromatawai Hauora Whaiaro:** Ka arotakehia whānuitia ō pūkete hauora e tētahi tīma maha-mātauranga (MDT) hei whakatau mēnā he pai te rongoā ADC mō tō āhua.
- **Whakangāwari i te Uru Atu ki te Manaaki:** Āwhina ki te tiki visa mō Haina, te whakarite i ngā hui kōrero mō ngā tohunga, te whakarite ratonga whakamaori, me te whakarite i te whakaurunga ki te hōhipera kia kore ai he āwangawanga.
### Whakapā mai inaianei mō ētahi atu kōrero
Mena kei te pāngia koe, tō whanaunga rānei e ngā wero e pā ana ki te mate pukupuku pūkahukahu iti wāhanga whānui, te mate pukupuku ihu, me ētahi atu pukupuku totoka kua whanake, ā, e hiahia ana koe ki te ako atu mō te rongoā ADC hou, ki te aromatawai rānei i ngā whai wāhitanga maimoatanga, whakapā atu ki te Tari Ao o te Hōhipera Oncology Rohe o Beijing South. Ka whakautua e ā mātou tohunga Ratonga Tūroro Ao tō patai i roto i ngā haora 24.
**Ngā Mōhiohio Whakapā:**
- **Waea:** 400-880-3716��
- **WeChat:** 17801183037
- **Īmēra:**
100085_010@163.com
myimmnet@163.com
E mārama ana mātou he uaua te ara o te maimoatanga mate pukupuku, engari ko ia putanga hou he tohu tumanako hou. Ko te Tari Ao o te Hōhipera Matepukupuku o te Rohe Tonga o Beijing e hiahia ana ki te tū tahi me koutou, me te whakamahi i ngā hangarau hauora tohunga me te manaaki mahana, aroha, kia taea ai e tātou te wikitoria i te mate pukupuku me te awhi i te tīmatanga o te ora.
Wā tuku: Maehe-24-2026