Kua Whiwhi Whakaaetanga Ā-Whānui a Vebreltinib i Haina mō te MET-Amplified NSCLC

I te 30 o Hune, i whiwhi te Vebreltinib, te aukati MET i whakawhanakehia motuhaketia e Avistone, i whakaaetia ā-ture mai i te National Medical Products Administration (NMPA) o Haina mō te maimoatanga o ngā tūroro he mate pukupuku pūkahukahu kore-pūtau iti (NSCLC) kua horapa ki te rohe, kua horapa rānei, e mau ana te whakanui MET. Koinei te tuatoru o ngā tohu kua whakaaetia mō Vebreltinib i Haina, ā, ko te rongoā kotahi-kaihoko tuatahi o te ao kua whakaaetia mō ngā tūroro NSCLC kua whakanuia ki te MET.

Ko te whakaaetanga o Vebreltinib i Haina mō tēnei tohu hou—e rongoā ana i ngā tūroro he mate pukupuku pūkahukahu kore-pūtau iti (NSCLC) kua horapa ki te rohe, kua horapa rānei, e mau ana te whakanui MET—i ahu mai i ngā hua pai mai i te Cohort 2 me te Cohort 3 o te rangahau KUNPENG (NCT04258033).

Ko te nuinga o te rōpū 2 i whakauru i ngā tūroro i rongoatia i mua me te NSCLC whakakaha MET i rahua i te maimoatanga paerewa (tae atu ki te chemotherapy e hangai ana ki te platinum), ko te nuinga ia o te rōpū 3 i whakauru i ngā tūroro kāore anō kia rongoatia me te NSCLC whakakaha MET i whakakahore i te chemotherapy.

E 86 ngā tūroro katoa me te NSCLC kua horapa ā-rohe, kua horapa rānei i whakaurua puta noa i ngā rōpū e rua (33 i roto i te Rōpū 2 me te 53 i roto i te Rōpū 3). I whakaatuhia e ngā hua o te rangahau he reiti urupare whānui (ORR) o te 48.8%, he reiti whakahaere mate (DCR) o te 77.9%, he roanga urupare waenga (DoR) o te 12.1 marama, he oranga kore-haere-ake waenga (PFS) o te 7.4 marama, me te oranga whānui waenga (OS) o te 13.9 marama.

I roto i te Rōpū 2 (33 ngā tūroro i rongoatia i mua), ko te ORR he 48.5%, ko te DCR he 78.8%, ko te DoR toharite he 11.0 marama, ko te PFS toharite he 6.2 marama, ā, ko te OS toharite he 11.7 marama.

I roto i te Rōpū 3 (53 ngā tūroro kāore anō kia whiwhi maimoatanga), ko te ORR he 49.1%, ko te DCR he 77.4%, ko te DoR toharite he 12.1 marama, ko te PFS toharite he 8.3 marama, ā, ko te OS toharite he 15.5 marama.

I roto i te rangahau KUNPENG, e 21 ngā tūroro kua horapa te mate ki te roro i arotakengia e te Komiti Arotake Motuhake (IRC). I roto i ēnei, 10 i whiwhi i ngā urupare hapa (PR) kua whakamanahia, ā, ko te hua he ORR o te 47.6%, he DCR o te 85.7%, me te DoR toharite o te 11.0 marama. Hei tāpiri, ko te PFS me te OS toharite he 8.3 marama me te 14.7 marama, ia.

I tēnei wā, he maha tonu ngā whakamātautau haumanu o ngā hangarau hou hei ārai i te matepukupuku i Haina e rapu ana i ngā tūroro. Mēnā kei te hiahia koe ki te kōrero mō ngā rongoā me ngā hangarau hou, ka taea e koe te whakapā atu ki te Tari Ao o te Hōhipera Oncology Rohe Tonga o Beijing.

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