I te 16 o Hūrae, i whakaputa te hautaka o te ao rongonui, a Nature Medicine, i ngā raraunga rangahau mō te SHR-A1904, he hononga paturopi-rongoā (ADC) e aro ana ki te claudin 18.2 (CLDN18.2), hei rongoā i te mate pukupuku puku matatau, te mate pukupuku hononga gastroesophageal rānei (GC/GEJC). I whakahaerehia e ngā kairangahau tētahi whakamātautau haumanu tuatahi, e toru ngā wāhanga, Wāhanga 1, i roto i te tangata, hei aromatawai i te whai huatanga o te SHR-A1904 i roto i te 95 o ngā tūroro i rongoatia i mua me te mate pukupuku G/GEJ matatau CLDN18.2-pai.
I tēnei wā, he maha tonu ngā whakamātautau haumanu o ngā hangarau hou hei ārai i te matepukupuku i Haina e rapu ana i ngā tūroro. Mēnā kei te hiahia koe ki te kōrero mō ngā rongoā me ngā hangarau hou, ka taea e koe te whakapā atu ki te Tari Ao o te Hōhipera Oncology Rohe Tonga o Beijing.
Tau Waea：4008803716
WeChat ID: 17801183037
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Ko te Claudin-18 isoform 2 (CLDN18.2), he pūmua hononga piripono e whakaatuhia ana i roto i te epithelium puku kore-kino, ā, e whakaatuhia ana ki te mata o te pūtau pukupuku i te wā o te whakawhiti kino, he ūnga rongoā whai hua mō ngā mate pukupuku hononga puku me te gastroesophageal (G/GEJ). Ko te SHR-A1904 he hononga paturopi-rongoā kei roto ko te paturopi monoclonal e arotahi ana ki te CLDN18.2, he kawenga aukati DNA topoisomerase I me te hononga peptide-cleavable.
I te wāhanga whakanui horopeta (0.6–8.0 mg kg−1), i kitea ngā paitini whakawhāiti horopeta i roto i ngā tūroro e rua i te 4.8 mg kg−1 (te neutropenia kirika taumata 3 me te bilirubin toto taumata 3 i piki ake) me te tūroro kotahi i te 6.0 mg kg−1 (te whara o te mucosal puku taumata 3). Kāore i eke ki te horopeta mōrahi e whakaaetia ana, ā, i tīpakohia te 6.0 mg kg−1 me te 8.0 mg kg−1 mō te pharmacokinetic me te whakawhānui i te whai huatanga. I puta ngā pānga kino puta noa i te maimoatanga i roto i ngā tūroro 95 katoa, ko te nuinga he anemia (72 (75.8%)), whakapairuaki (64 (67.4%)), hypoalbuminemia (61 (64.2%)) me te hekenga o te maha o ngā pūtau toto ma (56 (58.9%)). I tua atu, 59 ngā tūroro (62.1%) i pāngia e ngā pānga kino taumata 3, teitei ake rānei e pā ana ki te rongoā. Kāore he mate e pā ana ki te maimoatanga i pūrongohia. I roto i ngā tūroro ka taea te arotake i te urupare, ko te reiti urupare whaimana kua whakaūtia ko te 24.2% (95% wā whakawhirinaki (CI), 11.1–42.3) i te 6.0 mg kg−1 me te 25.0% (95% CI, 12.1–42.2) i te 8.0 mg kg−1. Ko te oranga toharite kore-whakahaere ko te 5.6 marama (95% CI, 3.0–6.9) i te 6.0 mg kg−1 me te 5.8 marama (95% CI, 3.0–8.6) i te 8.0 mg kg−1. Hei whakamutunga, i whakaatu a SHR-A1904 i tētahi kōtaha haumaru ka taea te whakahaere me te whakatenatena i te mahi ārai-puku i roto i ngā tūroro me te mate pukupuku G/GEJ CLDN18.2-pai, e tika ana kia rangahauhia anō.
I tēnei wā, he maha tonu ngā whakamātautau haumanu o ngā hangarau hou hei ārai i te matepukupuku i Haina e rapu ana i ngā tūroro. Mēnā kei te hiahia koe ki te kōrero mō ngā rongoā me ngā hangarau hou, ka taea e koe te whakapā atu ki te Tari Ao o te Hōhipera Oncology Rohe Tonga o Beijing.
Tau Waea：4008803716
WeChat ID: 17801183037
Email：myimmnet@163.com
Wā tuku: Hurae-24-2025