Ko te Glioblastoma Multiforme (GBM) tētahi o ngā mate pukupuku tino whakamate, ā, tata ki te katoa o ngā tūroro ka hoki anō ki te mate i runga i te paerewa tiaki o nāianei mō te GBM hou kua kitea. Ko te GBM e hoki anō ana (rGBM) e whakaatu ana i te oranga toharite o raro iho i te 8 marama me te iti o ngā kōwhiringa rongoā.
Ko te TX103 he rongoā whakaora pūtau CAR-T e aro ana ki te B7-H3, i whakawhanakehia motuhaketia, ā, i whakamanahia hoki e ngā patent Hainamana me te ao. Kua whakaaturia ngā hua haumanu tuatahi o te maimoatanga TX103 mō ngā glioma e hokihoki mai ana ki te Hui-ā-Tau a te American Society of Clinical Oncology (ASCO) i te tau 2024.（NCT05241392）.
Ngā Tikanga: He rangahau tuwhera tēnei, kotahi te ringa, he "3+3″ te whakanui i te horopeta me te horopeta maha. Ko te whāinga matua he aromatawai i te haumaru me te horopeta tino pai. Ko ngā whāinga tuarua ko ngā putanga oranga, ngā urupare pukupuku, ngā urupare ārai mate, me ngā tawhā pharmacokinetic. I whakaurua ngā tūroro i waenga i te 18 ki te 75 tau te pakeke me te hokinga mai kua whakaūtia mā te matawai whakaahua me te whakaaturanga B7-H3 >= 30% mā te tātaritanga ārai mate. I tukuna a TX103 ki roto i te kōhao me/ranei ki roto i te ventricular ki ngā tūroro mā te puna Ommaya. I hoatu a TX103 i ia rua wiki ki ngā tūroro i ia huringa i ngā taumata horopeta 1, 2, me te 3 (20, 60, 150 miriona pūtau, ia), me ngā huringa e whā hei akoranga kotahi.
Ngā Hua: I waenganui i te marama o Poutū-te-rangi 2022 me te marama o Hanuere 2024, 13 ngā tūroro i whiwhi i te iti rawa i te kotahi te werohanga o te TX103 ki roto i te angaanga, me te 3, 4, me te 6 ngā tūroro i ngā taumata horopeta 1, 2, me te 3. Ko te maha o ngā huringa werohanga he 4 (Mini, Max 1,9). I whakaurua ngā tūroro katoa ki te tātaritanga haumaru, e whakaatu ana kāore he paitini whakawhāiti horopeta, he mate rānei e pā ana ki te maimoatanga CAR-T. I pāngia ngā tūroro katoa i te iti rawa i te kotahi te pānga kino (AE), ā, ko ngā AE e pā ana ki te maimoatanga (TRAE) ko te mate tuku cytokine, te pikinga o te pēhanga o roto i te angaanga (ICP), te ānini, te mate haurangi, te hekenga o te māramatanga, te ruaki, me te pyrexia. Ko te nuinga o ngā TRAE he taumata 1-2, ā, e toru ngā TRAE taumata-3 i kitea: kotahi te take o te pikinga o te ICP i te taumata horopeta 2, kotahi te take o te mate haurangi, me tētahi atu take o te hekenga o te māramatanga i te taumata horopeta 3. I te marama o Hanuere 2024, e ono ngā tūroro mai i ngā taumata horopeta 1 me te 2 i āhei ki te aromatawai oranga 12-marama; Ko te reiti oranga whānui (OS) mō ngā marama 12 he 83.3% (95% CI: 58.3%~100%), ā, ko te OS toharite he 20.3 marama (95% CI: 20.3~kāore i tae atu). Tokorua o ngā tūroro e toru mai i te taumata horopeta 2 i whiwhi i ngā urupare hapa me ngā urupare katoa. Whai muri i te whakahaerenga CAR-T, i kitea he pikinga nui o ngā cytokine, tae atu ki te IL-6 me te IFN-γ, me te pikinga o ngā tau tārua o te ira CAR i roto i te wai cerebrospinal, engari he iti noa iho ngā pikinga i kitea i roto i te toto ā-taha.
Ngā Whakatau: I roto i tēnei whakamātautau, e kiia ana he haumaru, he manawanui hoki te rongoā i te rGBM ki te TX103. Ka tautokohia e ēnei hua wā poto ētahi atu rangahau mā te whakamahi i te TX103 hei whakarei ake i ngā putanga oranga o ngā tūroro me te rGBM.
I tēnei wā, he maha atu ngā whakamātautau haumanu CAR-T i Haina, ā, kei te rapu tūroro rātou. Mō te kōrerorero mō ngā rongoā me ngā hangarau hou, ka taea e koe te whakapā atu ki te Tari Ao o te Hōhipera Oncology Rohe Tonga o Beijing.
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Wā tuku: Hakihea-09-2024