I te 13 o Ākuhata, 2025, i tukuna e te paetukutuku o Te Wā o Te Moana-nui-a-Kiwa, te paetukutuku mana o te Huihuinga Ao mō te Mate Pukupuku Pūkahukahu (WCLC) 2025, ngā whakarāpopototanga rangahau kua tīpakohia mō te hui o tēnei tau. Kei roto i ngā kaupapa matua ko te whakarāpopototanga kua whakahoutia mō te whakamātautau haumanu Wāhanga 1 tuatahi i roto i te tangata o te HLX43, arā, ko te PD-L1 ADC a Henlius.
I tēnei wā, he maha tonu ngā whakamātautau haumanu o ngā hangarau hou hei ārai i te matepukupuku i Haina e rapu ana i ngā tūroro. Mēnā kei te hiahia koe ki te kōrero mō ngā rongoā me ngā hangarau hou, ka taea e koe te whakapā atu ki te Tari Ao o te Hōhipera Oncology Rohe Tonga o Beijing.
Tau Waea：4008803716
WeChat ID: 17801183037
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He ADC whānui-whānui te whānuitanga o te HLX43 hei ārai i te mate pukupuku e aro ana ki te PD-L1, e whakaatu ana i ngā tikanga rua e whakauru ana i te aukati i te ārai mate me te paitini pūtau e whakahaerehia ana e te kawenga. Kua whakaatuhia e ngā raraunga haumanu-mua he pai ngā pānga ārai mate pukupuku a HLX43, ā, he pai te manawanui ki te mate pukupuku pūkahukahu kore-pūtau iti (NSCLC), te mate pukupuku waha kōpū (CC), te mate pukupuku pūtau squamous esophageal (ESCC), me ētahi atu momo pukupuku he ātete ki te PD-1/L1 mAb.
E ai ki te whakarāpopototanga hou, kei te whakaatu tonu a HLX43 i te tere urupare teitei i roto i ngā tūroro he pukupuku totoka kua whanake, inā koa i roto i ngā tūroro NSCLC i mua i te maimoatanga i rahua te rongoā aukati tirotiro. He pai ake te whai huatanga o HLX43 i roto i ngā rōpū iti motuhake, me te tere urupare whāinga (ORR) o te 47.4% i roto i te NSCLC kore-squamous momo-mohoao EGFR, me te pupuri tonu i te kōtaha haumaru pai. He mea nui, he kaha te whai huatanga o HLX43 ahakoa te whakaaturanga PD-L1, e tohu ana i tōna pūmanawa ārai pukupuku kore-biomarker.
He Whai Hua i roto i te Maimoatanga o te NSCLC Ātete-CPI i te Rā Whakamutunga: I te 28 o Pēpuere, 2025, e 85 ngā tūroro i whiwhi HLX43. I te Wāhanga Ia (te pikinga o te horopeta), e 21 ngā tūroro me ngā pukupuku totoka kua whanake haere i whakaurua, i te Wāhanga Ib (te whakawhānui o te horopeta), e 64 ngā tūroro NSCLC i tohua puta noa i ngā rōpū e toru (2, 2.5, me te 3 mg/kg). He mea nui, 88.2% (75/85) o ngā tūroro i rahua i te rongoā aukati tirotiro (CPI) o mua.
Te Whai Huatanga Whakamiharo i roto i te NSCLC me ngā Hua Whakamiharo i roto i ngā Rōpū Iti Motuhake: I roto i ngā tūroro NSCLC 76 (69 ka taea te arotake i te whai huatanga), ko te ORR he 31.9% (22/69), me te reiti whakahaere mate (DCR) o te 87.0% (60/69). I whakaatuhia e ngā tātaritanga rōpū iti te whai huatanga whakamiharo o te HLX43 i roto i ngā taupori motuhake: ko ngā rōpū 2 mg/kg me te 2.5 mg/kg i te Wāhanga Ib i tutuki i a rātou ngā ORR o te 38.1% (8/21) me te 33.3% (7/21), ia; ko ngā tūroro NSCLC ātete-CPI (n=61) i whakaatu i te ORR o te 32.8% (20/61); ko ngā tūroro NSCLC kore-squamous momo-mohoao EGFR (n=19) he 47.4% (9/19).
Āhua Haumaru Pai, Whai Huatanga Nui me te Paitini Iti: I te Wāhanga Ia, kotahi te huihuinga DLT e pā ana ki te neutropenia kirika i kitea i roto i te rōpū 4 mg/kg. I pūrongohia ngā pānga kino e pā ana ki te maimoatanga (TRAE) i roto i te 95.2% o ngā tūroro, ko te nuinga he Tau 1-2. I puta ngā TRAE Tau ≥3 i roto i te 5 tūroro (23.8%), katoa mai i ngā rōpū 3 me te 4 mg/kg, ko te nuinga he hekenga o te maha o ngā neutrophil (19%), he hekenga o te maha o ngā pūtau toto ma (19.0%) me te anemia (14.3%). Ko ngā pānga kino e pā ana ki te ārai mate (irAE) i pūrongohia i roto i tēnei rangahau e kī ana ka taea e HLX43 te whakaputa pānga whakaora ārai mate. He mea nui, ko ngā tūroro i pūrongo i ngā irAE i whakaatu i te tere urupare whāinga teitei ake (ORR).
He whai hua i roto i ngā momo āhua o ngā tohu koiora: Ko ngā tūroro NSCLC PD-L1-pai (n=50) i whakaatu i te ORR o te 32.0% (16/50) i te mea ko ngā tūroro PD-L1-kino/kāore i te mōhiotia (n=19) i eke ki te ORR o te 31.6% (6/19), kāore he rerekētanga nui i kitea.
I tēnei wā, he maha tonu ngā whakamātautau haumanu o ngā hangarau hou hei ārai i te matepukupuku i Haina e rapu ana i ngā tūroro. Mēnā kei te hiahia koe ki te kōrero mō ngā rongoā me ngā hangarau hou, ka taea e koe te whakapā atu ki te Tari Ao o te Hōhipera Oncology Rohe Tonga o Beijing.
Tau Waea：4008803716
WeChat ID: 17801183037
Email：myimmnet@163.com
Wā tuku: 15 o Ākuhata-2025