Ngā Raraunga Hauora Tuatahi mō te Allogeneic BCMA CAR-T CT0596, e Whakaatu ana i te Haumaru me te Whai Huatanga Pai

I te 12 o Mei, 2025, ka pānuitia e CARsgen ngā raraunga haumanu tuatahi mō CT0596, he CAR-T allogeneic BCMA-arotahi i whakawhanakehia mā te whakamahi i te tūāpapa THANK-u Plus™. Kei te arotakehia a CT0596 i roto i tētahi rangahau haumanu tūhuratanga tuatahi mō te myeloma maha kua hoki mai/aukati (R/R MM) te leukemia pūtau plasma kua hoki mai/aukati rānei (R/R PCL) hei aromatawai i tōna haumaru, me tōna whai huatanga tuatahi.

I te 6 o Mei, 2025, e 8 ngā tūroro me te R/R MM kua whiwhi i te iti rawa e toru ngā raina rongoā o mua i whakaurua, ā, i werohia ki te CT0596 whai muri i te lymphodepletion me te tikanga FC (fludarabine 22.5-30 mg/m² me te cyclophosphamide 350-500 mg/m²). Ko ngā kitenga matua mai i te whā marama o te aroturukitanga ko:

Kāore i puta he pūrongo mō ngā paitini whakawhāiti-horopeta (DLT), te mate tuku cytokine ≥Grade 3 (CRS), te mate neurotoxicity e hono ana ki ngā pūtau pānga ārai mate (ICANS), te mate graft-versus-host rānei (GVHD). I whakaatuhia e te hua he āhua haumaru pai, me te korenga o ngā tūroro i mutu te maimoatanga nā ngā pānga kino.

1) I roto i te 5 o ngā tūroro i whakaoti i te aromatawai whai huatanga tuatahi i te Wiki 4, 3 ngā tūroro (60%) i tutuki i te urupare tino pakari/whakautu katoa (sCR/CR), ā, 4 ngā tūroro (80%) i tutuki i te iti rawa o te mate toenga (MRD)-kino i roto i te hinu wheua. 2) Ko ngā raraunga whai huatanga wawe mai i te 2 o ngā tūroro i te Rā 14 i whakaatu i te whakahekenga o ngā whara ine mā te ≥92% me te ≥65%, ia. 3) Kāore anō kia tae te 1 o ngā tūroro ki te wā aromatawai whai huatanga kua tohua e te kawa.

I noho tonu ngā urupare a ngā tūroro sCR/CR katoa, tae atu ki te tūroro tuatahi i whakaoti i te aroturukitanga e whā marama te roa.

I runga i ngā raraunga haumaru me te whai huatanga tuatahi, i whakaatu a CT0596 i te manawanui pai me te whakatenatena i ngā tohu whai huatanga i roto i ngā tūroro R/R MM puta noa i ngā taumata horopeta kua tautuhia i mua, me te kite i te whānui o te CAR-T. Me rangahau anō ēnei kitenga, ehara i te mea ko te R/R MM anake, engari ko ētahi atu mate pukupuku pūtau plasma me ngā mate pūnaha ārai mate e pāngia ana e ngā pūtau plasma autoreactive.

I tēnei wā, he maha tonu ngā whakamātautau haumanu o ngā hangarau hou hei ārai i te matepukupuku i Haina e rapu ana i ngā tūroro. Mēnā kei te hiahia koe ki te kōrero mō ngā rongoā me ngā hangarau hou, ka taea e koe te whakapā atu ki te Tari Ao o te Hōhipera Oncology Rohe Tonga o Beijing.

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