I whakaurua te PLB1004 ki te rongoā hou

Ko te PLB1004, i whakawhanakehia e Beijing Avistone Biotechnology Co., Ltd., he aukati tyrosine kinase epidermal growth factor receptor (EGFR-TKI) haumaru, tino whiriwhiri, me te whai hua e whakamahia ana hei rongoā i te matepukupuku pūkahukahu kore-pūtau-iti (NSCLC).

I te 9 o Paenga-whāwhā, 2025, i whakaatuhia e te National Medical Products Administration Drug Evaluation Center (CDE) ko te PLB1004 o Beijing Avistone Biotechnology i whakaarohia kia whakaurua ki roto i te maimoatanga hou mō ngā tūroro he mate pukupuku pūkahukahu kore-pūtau iti (NSCLC) kei te whanake haere i te rohe, he mate pukupuku pūkahukahu METastatic rānei, ā, he whakarerekētanga EGFR, he whakanui met met me/ranei he nui rawa te whakaputa i muri i te korenga o te maimoatanga EGFR-TKI.

I pānuitia ngā hua haumanu tuatahi o te PLB1004 i honoa ki te Vebreltinib i te maimoatanga o ngā tūroro matepukupuku pūkahukahu ehara i te pūtau iti me ngā whakarerekētanga EGFR, te whakanui MET, te whakanui rawa rānei o te MET i muri i te EGFR-TKI i te Huihuinga Ao mō te Matepukupuku Pūkahukahu 2024.

E whā tekau mā whā ngā tūroro i whiwhi i te Vebreltinib 100mg me te PLB1004 160mg (n=15), Vebreltinib 150mg me te PLB1004 160mg (n=13), Vebreltinib 200mg me te PLB1004 80mg (n=3), Vebreltinib 150mg me te PLB1004 80mg rānei (n=13) ā, i whakaurua ki te tātaritanga haumaru whānui. I roto i ngā tūroro 44 i arotakengia, 36.4% o ngā tūroro kua horapa te roro, ā, 86.4% o ngā tūroro kua whiwhi i te EGFR-TKI o te whakatupuranga tuatoru. I puta ngā urupare whāinga puta noa i ngā taumata horopeta Vebreltinib me PLB1004 katoa i whakamatautauria, me ngā urupare wāhanga (PR) i kitea i roto i te 19/32 (59.4%) o ngā tūroro ka taea te arotake urupare. I roto i ngā tūroro kua horapa te roro, ko te ORR he 75.0% (9/12). Ko te ORR he 58.6% (17/29) i roto i ngā tūroro i whiwhi i te EGFR-TKI o te whakatupuranga tuatoru o mua. Ko ngā TRAE tino kitea ko te ponana me te paronychia. Kāore he tūroro i mutu te maimoatanga nā te TRAE.

I tēnei wā, he maha tonu ngā whakamātautau haumanu o ngā hangarau hou hei ārai i te matepukupuku i Haina e rapu ana i ngā tūroro. Mēnā kei te hiahia koe ki te kōrero mō ngā rongoā me ngā hangarau hou, ka taea e koe te whakapā atu ki te Tari Ao o te Hōhipera Oncology Rohe Tonga o Beijing.

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