Kua Whakaaetia te Pembrolizumab i Haina mō te HCC Kāore e Taea te Tātari i te Whakakotahitanga me Lenvatinib me TACE

Nō nā tata nei, i kī a Merck & Co., Inc. (Merck) kua whakaaetia te pembrolizumab, te aukati PD-1, e te National Medical Products Administration (NMPA) o Haina, kia whakamahia ngātahitia me te lenvatinib me te transarterial chemoembolization (TACE) hei rongoā i ngā tūroro he mate pukupuku hepatocellular kāore e taea te tango, kāore hoki e horapa.

Ko te whakaaetanga o tēnei tohu hou i ahu mai i ngā raraunga mai i te whakamātautau haumanu Wāhanga III LEAP-012. I roto i tēnei rangahau Wāhanga III maha-pokapū, matapōkeretia, matapo-rua (LEAP-012), 480 ngā tūroro i whakaurua, ā, i tohaina matapōkeretia kia whiwhi i te lenvatinib me te TACE me te pembrolizumab (n=237) me te TACE me te placebo takirua rānei (n=243).

I whakaatuhia e ngā hua ko te roanga oranga kore-whakahaere (PFS) he 14.6 marama i roto i te rōpū lenvatinib me te TACE me te pembrolizumab, ki te whakaritea ki te 10.0 marama i roto i te rōpū placebo. Ko ngā reiti oranga whānui (OS) 24-marama he 75% me te 69%, ia.

Lenvatinibhe aukati kinase e whakamahia ana hei rongoā i ētahi momo mate pukupuku. Ko ngā aukati kinase he aukati whākōkī e aukati ana i te mahi a tētahi, neke atu rānei o ngā kinase pūmua.

Ko te Pembrolizumab he paturopi IgG4 kappa monoclonal kua whakawhaiarotia ki te tangata e aro ana ki te PD-1 (kaiwhakawhiwhi mate kua whakaritea) i runga i ngā lymphocytes. Ka whakaratohia e te kaiwhiwhi PD-1 he "tirotiro ārai mate" nui, e āwhina ana ki te aukati i te pūnaha ārai mate kei whakaeke i a ia anō. He nui te whakaaturanga o te PD-L1 (ligand kaiwhiwhi mate kua whakaritea) i roto i ētahi momo pukupuku. Ko ētahi atu momo pukupuku ka whakamahi i te ātete ārai mate urutau e tango ana i te āhua tūturu o te whakaoho PD-L1 (te tiaki i te kino e puta mai ana i te ārai mate mai i ngā mate) ka urutau ki ngā urupare ārai-pukupuku. Ina uru te PD-L1 ki te PD-1, ka aukatihia te mahi pūtau-T; ka aukati te pembrolizumab i te hanganga matatini PD-1: PDL-1 e āhei ai te whakapai ake i te whakamatenga e puta mai ana i te pūtau-T.

I tēnei wā, he maha tonu ngā whakamātautau haumanu o ngā hangarau hou hei ārai i te matepukupuku i Haina e rapu ana i ngā tūroro. Mēnā kei te hiahia koe ki te kōrero mō ngā rongoā me ngā hangarau hou, ka taea e koe te whakapā atu ki te Tari Ao o te Hōhipera Oncology Rohe Tonga o Beijing.

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