I te 31 o Hūrae, i panuitia ngātahitia e AstraZeneca me Merck & Co. kua whakaaetia tā rātou aukati PARP Lynparza, me Abiraterone me te prednisolone, i Haina mō te maimoatanga o ngā tūroro pakeke e pāngia ana e te mate pukupuku repeure metastatic castration-resistant (mCRPC) e mau ana i ngā whakarerekētanga BRCA germline, somatic rānei (gBRCAm, sBRCAm rānei).
I tēnei wā, he maha tonu ngā whakamātautau haumanu o ngā hangarau hou hei ārai i te matepukupuku i Haina e rapu ana i ngā tūroro. Mēnā kei te hiahia koe ki te kōrero mō ngā rongoā me ngā hangarau hou, ka taea e koe te whakapā atu ki te Tari Ao o te Hōhipera Oncology Rohe Tonga o Beijing.
Tau Waea：4008803716
WeChat ID: 17801183037
Īmēra：myimmnet@163.com
Ko Lynparza (olaparib) te tuatahi o ngā aukati PARP o tōna akomanga, ā, ko te maimoatanga tuatahi hei aukati i te urupare kino DNA (DDR) i roto i ngā pūtau/pūpū e mau ana i te ngoikore o te HRR, pērā i ngā whakarerekētanga ira i roto i te BRCA1 me/ranei te BRCA2. Mā te aukati i te PARP me Lynparza ka mau te PARP e herea ana ki ngā wehenga aho kotahi o te DNA, ka whakaroa i ngā marau tāruarua, ka hinga, ka puta ngā wehenga aho rua o te DNA, ka mate hoki ngā pūtau matepukupuku.
Ko te nuinga o tēnei whakaaetanga i ahu mai i ngā hua tātaritanga rōpū iti mai i ngā rōpū ā-ao me Haina o te whakamātautau PROpel Wāhanga III. He whakamātautau haumanu matapōkere, matapo-rua, maha-pokapū a PROpel Wāhanga III e aromatawai ana i te whai huatanga, te haumaru, me te manawanui ki a Lynparza i te taha o Abiraterone me te prednisolone ki te whakataurite ki te placebo me Abiraterone me te prednisolone i roto i ngā tūroro tāne me te mCRPC kāore anō kia whiwhi i te chemotherapy o mua, i te rongoā homoni hou rānei (NHA) i te wāhanga mCRPC.
I whakaatuhia e ngā raraunga mai i te rōpū tūroro ā-ao me ngā whakarerekētanga BRCA, i whakaatuhia e Lynparza me Abiraterone he whakapainga nui ki te oranga kore-haere whakamua (rPFS) i roto i te whakaahua X-ray ki te whakataurite ki te Abiraterone monotherapy. I whakaatuhia e te tātaritanga rōpū iti o ngā tūroro me ngā whakarerekētanga BRCA i roto i te rōpū ā-ao, i whakaitihia e Lynparza me Abiraterone te mōrearea o te haere whakamua o te mate, te mate rānei mā te 76% me te mōrearea o te mate mā te 70%. Kāore anō kia eke te rPFS toharite me te oranga whānui (OS) toharite i roto i te rōpū Lynparza me Abiraterone, engari ko te rPFS toharite me te OS toharite i roto i te rōpū Abiraterone monotherapy he 8 marama me te 23 marama, ia.
I tēnei wā, he maha tonu ngā whakamātautau haumanu o ngā hangarau hou hei ārai i te matepukupuku i Haina e rapu ana i ngā tūroro. Mēnā kei te hiahia koe ki te kōrero mō ngā rongoā me ngā hangarau hou, ka taea e koe te whakapā atu ki te Tari Ao o te Hōhipera Oncology Rohe Tonga o Beijing.
Tau Waea：4008803716
WeChat ID: 17801183037
Email：myimmnet@163.com
Wā tuku: Akuhata-07-2025