Nō nā tata nei, i panuitia e Ascentage Pharma kua whakaaetia e te Whakahaere Hua Hauora ā-Motu o Haina (NMPA) tana aukati whiriwhiri Bcl-2 hou, a lisaftoclax (APG-2575), hei rongoā mō ngā tūroro pakeke e pāngia ana e te mate pukupuku toto lymphocytic mau tonu/te mate pukupuku toto lymphocytic iti (CLL/SLL) kua whiwhi i te iti rawa i te kotahi rongoā pūnaha tae atu ki ngā aukati Bruton's tyrosine kinase (BTK), e mea ana ko lisaftoclax te aukati Bcl-2 tuatahi e whiwhi ana i te whakaaetanga ā-ture me te whakamanatanga hokohoko mō te rongoā i ngā tūroro e pāngia ana e te CLL/SLL i Haina, me te tuarua o ngā aukati Bcl-2 kua whakaaetia puta noa i te ao.
Ko Lisaftoclax he aukati whiriwhiri Bcl-2 hou, he mea hou e tukuna ana ki te waha, i whakawhanakehia e Ascentage Pharma hei rongoā i ngā tūroro he mate pukupuku mā te aukati i te pūmua antiapoptotic Bcl-2, ā, nō reira ka whakahokia mai te tukanga apoptosis noa i roto i ngā pūtau mate pukupuku. I roto i ngā whakamātautau haumanu, kua whakaatuhia e lisaftoclax he kaha rongoā whānui i roto i ngā mate pukupuku toto maha me ngā pukupuku totoka, inā koa i roto i te CLL/SLL, hei rongoā kotahi me te rongoā whakakotahi.
Ko tēnei whakaaetanga i ahu mai i ngā hua o tētahi rangahau matua mō te Wāhanga II o te rēhitatanga (APG2575CC201) i hangaia hei aromatawai i te whai huatanga me te haumaru o te lisaftoclax monotherapy i roto i ngā tūroro he CLL/SLL kua hoki mai, he uaua rānei ki te rongoā, me te reiti urupare whānui (ORR) hei pito whakamutunga matua. I whakaatu a Lisaftoclax i te whai huatanga whakamiharo me te ORR i tutuki i te pito whakamutunga kua tohua i roto i ngā tūroro i rongoatia i mua ki ngā aukati BTK me/ranei te immunochemotherapy. I tua atu, i whakaatu a lisaftoclax i tētahi kōtaha haumaru pai me te kore he mate pukupuku-lysis (TLS) i puta i te wā o te rangahau, he iti te auau o ngā paitini toto i taea te whakahaere, me te iti o te auau o ngā paitini kore-toto i te nuinga o te wā he taumata 1-2.
Ko te CLL/SLL he mate pukupuku toto e puta mai ana i ngā pūtau-B pakeke. Ko te nuinga o te wā ka pā ki ngā taupori kaumātua, neke atu i te 100,000 ngā mate hou e pūrongohia ana puta noa i te ao i ia tau1. I Haina, he iti iho te auau o te CLL/SLL i ērā o ngā whenua o te uru, kei te tere piki haere te tere o te mate, me te pakeke taitamariki me te kaha ake o te pukuriri2. Hei whiringa matua o nāianei mō te maimoatanga raina-tuatahi o te CLL/SLL, kua tino pai ake te putanga maimoatanga mō ngā tūroro e ngā aukati BTK. Heoi, kei te aro tonu ngā aukati BTK ki ngā momo take pēnei i te iti o te kaha ki te whakaoho i ngā urupare hohonu, te nui o te mōrearea o te hokinga mai i te maimoatanga waenga me te roa, ngā paitini me te kore e taea te manawanui e pā ana ki te maimoatanga roa; nō reira, me rapu kōwhiringa maimoatanga haumaru ake, whai hua ake hoki mō ngā tūroro me te CLL/SLL.
Nā te whakaurunga mai o ngā aukati Bcl-2 i tino huri te maimoatanga o te CLL/SLL. Ko te take aukati apoptosis Bcl-2, e nui rawa ana te whakaputanga i roto i ngā momo mate toto, inā koa ko te CLL/SLL, he tikanga matua e karo ai ngā pūtau pukupuku i te apoptosis. Heoi, he tino uaua te kitenga o te aukati Bcl-2 hei whāinga rongoā nā te mea ko tana tikanga mahi e hangai ana ki te taunekeneke pūmua-pūmua (PPI). He nui te hononga here o te Bcl-2, e uaua ai mō ngā aukati ngota iti te whakamahi i ngā pānga aukati. Hei tāpiri, kei runga i te mitochondria te pūmua Bcl-2, me te hanganga membrane-rua, ko tētahi o ngā wāhanga pūtau tino uaua me te wero nā te mea me uru tuatahi ngā rongoā ki roto i te membrane pūtau i mua i te mahi anō ki te membrane mitochondrial. I mua atu i tēnei, kāore anō kia whakaaetia he aukati Bcl-2 mō te maimoatanga o te CLL/SLL i Haina. Mā tēnei whakaaetanga mō te lisaftoclax ka whakakīia he āputa maimoatanga i roto i te CLL/SLL, ka whakahokia mai he tumanako hou ki te maha o ngā tūroro i te whenua.
I tēnei wā, he maha tonu ngā whakamātautau haumanu o ngā hangarau hou hei ārai i te matepukupuku i Haina e rapu ana i ngā tūroro. Mēnā kei te hiahia koe ki te kōrero mō ngā rongoā me ngā hangarau hou, ka taea e koe te whakapā atu ki te Tari Ao o te Hōhipera Oncology Rohe Tonga o Beijing.
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Wā tuku: Hurae-15-2025