I te tīmatanga o Poutū-te-rangi, i whakaaetia e te National Medical Products Administration te Jaypirca® (pirtobrutinib) hei rongoā mō ngā tūroro pakeke e pāngia ana e te mate pukupuku toto toto mau tonu (CLL) me te mate pukupuku toto toto iti (SLL) kua whiwhi i te iti rawa i te kotahi te rongoā pūnaha o mua, tae atu ki te aukati i te Bruton's tyrosine kinase (BTK).
He aukati kinase tino whiriwhiri a Pirtobrutinib e whakamahi ana i tētahi tikanga here kore-tauhohe hou hei whakawhānui ake i te painga o te arotahi ki te ara BTK i roto i ngā tūroro CLL/SLL i rongoatia i mua ki tētahi aukati BTK tauhohe (ibrutinib, acalabrutinib, zanubrutinib rānei). I whakaaetia a Pirtobrutinib e te US FDA i te marama o Hanuere 2023 hei aukati BTK kore-tauhohe (whakahoki). I te marama o Oketopa 2024, i whakaaetia te pirtobrutinib i Haina hei rongoā kotahi mō ngā tūroro pakeke me te lymphoma pūtau mantle kua hoki mai, kua ātete rānei ki te rongoā, kua whiwhi i mua i te rua o ngā maimoatanga pūnaha o mua, tae atu ki tētahi aukati tyrosine kinase (BTK) a Bruton.
Ko te whakaaetanga o tēnei tohu hou i ahu mai i ngā hua o te rangahau ā-ao, maha-pokapū, matapōkeretia, Wāhanga 3 BRUIN CLL 321. Ko BRUIN CLL 321 te whakamātautau matapōkeretia tuatahi o te ao i whakahaerehia i roto i ngā tūroro me te CLL/SLL i rongoatia i mua ki te aukati BTK covalent (cBTKi). I whakaurua e te rangahau te katoa o ngā tūroro 238, ā, i aromatawaihia te whai huatanga me te haumaru o te pirtobrutinib monotherapy me te whiringa a te kairangahau o IdelaR (idelalisib me te rituximab) BR rānei (bendamustine me te rituximab). I whakaatuhia e ngā hua i roa ake te oranga kore whanaketanga (PFS) i te wa i whakaritea ki te maimoatanga whiriwhiri a te kairangahau (14.0 marama vs 8.7 marama; ōwehenga mōrearea [HR] = 0.54). Hei tāpiritanga, ko te auau whakamutu i te rongoā nā ngā pānga kino e pā ana ki te maimoatanga he iti iho i te pirtobrutinib (5.2% vs 21.1%), e tautoko ana i tōna whai huatanga me ōna painga manawanui i roto i ngā tūroro i rongoatia i mua ki te aukati BTK covalent.
Whakapā mai ki a mātou hei tīmata i tāu haerenga o te tumanako
E whakapau kaha ana te Tari Ao o te Hōhipera Matepukupuku o te Rohe Tonga o Beijing ki te whakarato i ngā maimoatanga matepukupuku matatau ki ngā tūroro o te ao. Mena kei te pāngia koe, tō mema rānei o te whānau e te matepukupuku, ā, kāore i te pai te urupare ki ngā maimoatanga tuku iho, kua rite tā mātou tīma Ratonga Tūroro Ao ki te whakarato ki a koe ngā mōhiohio taipitopito me ngā mahere maimoatanga whaiaro.
Tena koa whakapā mai ki a mātou mā roto i ēnei huarahi hei ako atu mō ngā kōwhiringa maimoatanga matepukupuku:
- Waea: 400-880-3716
- WeChat: 17801183037
- Email: 100085_010@163.com or myimmnet@163.com (Emails are welcome, and we will respond promptly)
Kei te tumanako te Tari Ao o te Hōhipera Matepukupuku o te Rohe Tonga o Beijing ki te mahi tahi me koe i roto i te pakanga ki te mate pukupuku. Ahakoa kei hea koe i te ao, e whakapau kaha ana mātou ki te whakarato ki a koe te tautoko hauora tino ngaio me te manaaki aroha.
Take the first step towards overcoming your illness. Call us at 400-880-3716 or contact us via WeChat at 17801183037 today. You can also email us at 100085_010@163.com or myimmnet@163.com to schedule a one-on-one consultation with our team of experts.
Wā tuku: Maehe-12-2026