I te 11 o Ākuhata, i tohu te Center for Drug Evaluation (CDE) o te National Medical Products Administration (NMPA) kua whakaarohia te tono a InxMed mō ngā papa IN10018 hei tohu rongoā hou, he mea hanga hei whakakotahi me te D-1553 hei rongoā i te mate pukupuku colorectal (CRC) kua horapa, kua horapa rānei, kua whiwhi i te iti rawa kia rua ngā momo rongoā o mua.
I tēnei wā, he maha tonu ngā whakamātautau haumanu o ngā hangarau hou hei ārai i te matepukupuku i Haina e rapu ana i ngā tūroro. Mēnā kei te hiahia koe ki te kōrero mō ngā rongoā me ngā hangarau hou, ka taea e koe te whakapā atu ki te Tari Ao o te Hōhipera Oncology Rohe Tonga o Beijing.
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Mō Ifebemtinib (IN10018)
Ko te Ifebemtinib (IN10018) he aukati ngota iti tino whiriwhiri, e tukuna ana ki te waha, he mea tino pai te mahi tahi me te whānuitanga o ngā momo rongoā. I roto i te haumanu, kua whakaatuhia e ia he mahi tahi rongoā me te chemotherapy, ngā maimoatanga kua arotahihia, me ngā immunotherapy. Tae noa ki tēnei wā, neke atu i te 600 ngā tūroro kua rongoatia me te kōtaha haumaru me te manawanui pai.
I te Hui-ā-Tau a te ASCO i te tau 2025, i tukuna ngā raraunga haumanu hou mai i te whakamātautau haumanu Wāhanga Ib/II (NCT06166836; NCT05379946) hei aromatawai i te whai huatanga me te haumaru o te ifebemtinib (IN10018), he aukati kinase piri ā-waha (FAK) me te garsorasib (D-1533), he aukati KRAS G12C ā-waha, i roto i ngā pukupuku totoka whakarerekētanga KRAS G12C.
Ko ngā raraunga haumanu i whakaaturia i te Hui-ā-Tau a te ASCO 2025 (Whakarāpopototanga #8629 | Papa Pānui #109) i whakaurua ngā hua mai i ngā rōpū e rua:
Ngā raraunga aroturuki i te pakari o te rōpū ringa kotahi i roto i ngā tūroro mate pukupuku pūkahukahu kore-pūtau iti (NSCLC) raina tuatahi KRAS G12C-mutant, ahakoa te whakaaturanga PD-L1, i whiwhi maimoatanga ifebemtinib + garsorasib.
He rōpū matapōkere i roto i ngā tūroro mate pukupuku koroni (CRC) kua rongoatia i mua, he KRAS G12C-mutant, e whakarite ana i te ifebemtinib+ garsorasib me te garsorasib monotherapy.
I roto i te rōpū NSCLC, ko te whakakotahitanga o te ifebemtinib me te garsorasib, hei rongoā ā-waha-rua, kāore he rongoā chemotherapy, i whakaatu i ngā painga haumanu whakamiharo tae atu ki ngā reiti urupare teitei me te whai huatanga pumau, ahakoa te whakaaturanga PD-L1, ā, i roto i te rōpū CRC, i whakaatu te hua i te whai huatanga tāpiri mārama a te ifebemtinib ki te whakataurite ki te rongoā kotahi a te aukati KRAS.
Ngā Kaupapa Matua o te NSCLC Rārangi Tuatahi: E whakaatu ana te Tikanga Rua-Waha i te Whai Huatanga Pumau me te Painga Ora Hou
I te 31 o Poutū-te-rangi, 2025, e 33 ngā tūroro NSCLC rārangi tuatahi, ahakoa te āhua o te PD-L1, i whakaurua, ā, i whiwhi i te huinga o te ifebemtinib me te garsorasib, me te roanga o te aroturukitanga toharite o te 16.0 marama. I mua, kua ripoatahia e te kamupene he reiti Whakautu Whāinga (ORR) o te 90.3% (ngā raraunga i whakaaturia i te ESMO 2024). Kua whakarāpopototia ngā raraunga aroturukitanga penei:
Te oranga kore-whakahaerenga waenga (mPFS): 22.3 marama
Te roanga waenga o te urupare DOR (mDOR): 19.4 marama
Te oranga whānui waenga (mOS): kāore anō kia eke ki te taumata, me te piki haere me te papatahi o te ānau oranga e tohu ana i te painga pumau.
He mea nui kia mōhiotia, i whakaatu te maimoatanga i te whai huatanga pumau ahakoa te āhua o te whakaaturanga PD-L1.
Ngā Kitenga Matua i roto i te CRC i Maimoatia i Mua: Ko te Whakamātautau Matapōkere e Whakamana ana i te Mahi Tahi me te KRAS G12Ci
I te 21 o Paenga-whāwhā, 2025, e 36 ngā tūroro CRC i rongoatia i mua i te rongoā i matapōkeretia 1:1 kia whiwhi i te huinga o te ifebemtinib + garsorasib, te garsorasib rānei anake. I arotakehia ngā tūroro katoa mā te hihi-X, ā, i aromatawaihia ngā urupare ārai-pukupuku, ā, i whakarāpopototia penei:
ORR: 44.4% (huinga) vs. 16.7% (mono)
Te auau whakahaere mate (DCR): 100.0% (huihuinga) vs. 77.8% (kotahi)
mPFS: 7.7 marama (huihuinga) vs. 4.0 marama (kotahi)
mOS: kāore anō kia tae ki te ringa whakakotahi; i kitea te wehenga wawe i roto i ngā ānau ora
I tēnei wā, he maha tonu ngā whakamātautau haumanu o ngā hangarau hou hei ārai i te matepukupuku i Haina e rapu ana i ngā tūroro. Mēnā kei te hiahia koe ki te kōrero mō ngā rongoā me ngā hangarau hou, ka taea e koe te whakapā atu ki te Tari Ao o te Hōhipera Oncology Rohe Tonga o Beijing.
Tau Waea：4008803716
WeChat ID: 17801183037
Email：myimmnet@163.com
Wā tuku: 13 o Ākuhata 2025