I te 31 o Poutū-te-rangi, 2026, i tukuna mai e te Pokapū Arotake Rongoā o te Whakahaere Hua Hauora ā-Motu o Haina he rongo whakahihiri: kua whakaurua mana a GFH375, i whakawhanakehia e GenFleet Therapeutics, hei "Whakaora Pakari" mō te maimoatanga o ngā tūroro he mate pukupuku repe taikaha kua horapa kei roto te whakarerekētanga KRAS G12D kua whiwhi i te iti rawa i te kotahi te rongoā pūnaha o mua. He tohu tēnei i tētahi taahiraa nui ki mua i te mara o te rongoā tika mō te mate pukupuku repe taikaha.
Mena kei te raru koe, kei te raru rānei tētahi o ō whanaunga i te mate pukupuku repe taikaha KRAS G12D-mutant kua horapa, kaua e ngoikore te tumanako. Kei te whai tata te Tari Ao o te Hōhipera Oncology Rohe Tonga o Beijing (400-880-3716) i tēnei whanaketanga hou, ā, kei te tuku ratonga kōrero ngaio me te whakarite maimoatanga mō ngā tūroro o te ao.
**Mō GFH375/VS-7375**
He aukati KRAS G12D (ON/OFF) ngota iti kaha-waha, kaha, me te tino whiriwhiri a GFH375, i hangaia hei arotahi ki te whakawhiti GTP/GDP, ā, ka whakararu i te whakahohenga o te ara o raro, ā, ka ārai pai i te tipu o ngā pūtau pukupuku. I whakaatuhia e ngā rangahau haumanu-mua te aukati e whakawhirinaki ana ki te horopeta i roto i ngā tauira e mau ana i ngā whakarerekētanga KRAS G12D; i whakaatuhia hoki e GFH375 te iti o te mōrearea i waho o te ūnga i roto i ngā whakamātautau tīpakonga kinase me te ūnga haumaru.
I uru atu a GenFleet ki tētahi mahi tahi ki te kimi me te whakawhanake me Verastem Oncology (Nasdaq: VSTM) hei whakatairanga i ngā kaupapa oncology hou e toru e aro ana ki ngā mate pukupuku e ārahihia ana e te ara RAS/MAPK. Mā te mahi tahi ka hoatu ki a Verastem tētahi kōwhiringa motuhake ki te whiwhi raihana mō ia o ngā matū e toru i muri i te otinga angitu o ngā tohu kua whakaritea i roto i tētahi whakamātautau Wāhanga Tuatahi. I te Hakihea 2023, i whiriwhiria e Verastem te GFH375/VS-7375, he aukati KRAS G12D (ON/OFF) ā-waha, hei kaupapa matua mai i te mahi tahi, ā, ko te raihana mō GFH375 i whakamahia i te Hanuere 2025 ko te tuatahi mai i tēnei mahi tahi. Mā ngā raihana ka hoatu ki a Verastem ngā mana whakawhanake me te arumoni i waho o Haina, ko GenFleet ia e pupuri ana i ngā mana i roto i Haina.
**Ngā raraunga whakamātautau haumanu Wāhanga I/II i whakaatuhia i te Huihuinga ESMO 2025:**
- 91.5% o ngā tūroro i pāngia e te whakahekenga o ngā whara ūnga
- I eke te reiti urupare whāinga (ORR) ki te 40.7%
- Ko te tere whakahaere mate (DCR) i eke ki te 96.7%
- Ko te toharite o te oranga kore-whakahaere (mPFS) he 5.52 marama
- Ko te reiti oranga mō ngā marama e 4 kāore he whanaketanga he 78.2%
Ko ēnei raraunga, i ahu mai i te 59 tūroro me te KRAS G12D-mutant pancreatic ductal adenocarcinoma (PDAC) matatau kua whiwhi i te rongoā pūnaha o mua, e whakaatu kaha ana i te kaha ārai-puku o GFH375 i roto i te mate pukupuku pancreatic uaua.
**He aha i whiriwhiri ai i te Tari Ao o te Hōhipera Matepukupuku o te Rohe Tonga o Beijing?**
Hei paionia i roto i ngā ratonga hauora o te ao, e whakapau kaha ana te Tari Ao o te Hōhipera Matepukupuku o te Rohe Tonga o Beijing ki te whakarato ki ngā tūroro o te ao:
- Ngā ratonga kōrero hauora ngaio reo maha me ngā ratonga whakarite wā
- Te urunga atu ki ngā tohunga matepukupuku matua o Haina me te ao whānui
- Te hongere matomato kotahi-mutunga mō te maimoatanga hauora whakawhiti-rohe
E mārama ana mātou, mō ngā tūroro e pāngia ana e te mate pukupuku kua pāngia e te mate pukupuku, ka nui ake te mōrearea i ia rā tatari tāpiri. Nō reira, kua whakatūhia e mātou he maha ngā hongere whakapā ā-ao kia pai ai te whiwhi tautoko ngaio i te wā tika.
**Whakapā mai ki a mātou i tēnei rā, tīmatahia tō haerenga o te tumanako**
�� Waea Whakapā: 400-880-3716
�� WeChat: 17801183037
�� Īmēra:
- 100085_010@163.com
- myimmnet@163.com
Ahakoa te whenua, te rohe rānei e noho ana koe, me te maha o ngā whiringa maimoatanga kua whakamatauria e koe, kua rite te Tari Ao o te Hōhipera Matepukupuku o te Rohe Tonga o Beijing ki te tautoko i a koe i roto i tō pakanga ki te mate pukupuku. Ko te ahunga whakamua o GFH375 pea te māramatanga kua tatarihia e koe.
Call 400-880-3716, add us on WeChat at 17801183037, or email us at 100085_010@163.com or myimmnet@163.com.
Kia kaha tātou katoa ki te whakatutuki i ngā whāinga maha atu o te ao.
> Kia mōhio: Kāore anō kia whakaaetia mana te GFH375 mō te hokohoko ki Haina matua. E matapaetia ana ka tere ake te urunga mai ki ngā rongoā haumanu nā tōna tohu Breakthrough Therapy. Ka aro turukihia e te Tari Ao o te Hōhipera Oncology Rohe Tonga o Beijing te ahunga whakamua o te urunga mai ki ngā rongoā, ā, ka whakaratohia he mōhiohio mō ngā maimoatanga hou me ngā ratonga whakarite mō ngā tūroro e tika ana. Me whai i ngā tohutohu a tō tākuta mō ngā mahere maimoatanga motuhake.
Wā tuku: Paenga-whāwhā-10-2026