I te 24 o Paenga-whāwhā, 2025, i panuitia e GenFleet Therapeutics kua whakaaetia e te US Food and Drug Administration (FDA) te whakamahinga rongoā hou (IND) o te GFH375/VS-7375, he aukati KRAS G12D (ON/OFF) ā-waha, mō te whakamātautau haumanu e rongoā ana i ngā tūroro pukupuku totoka matatau e mau ana i te whakarerekētanga KRAS G12D. Kua whakamaheretia kia tīmatahia te rangahau e te hoa o GenFleet, a Verastem Oncology, i te US i waenganui o te tau 2025. Kua neke whakamua te rangahau tuatahi i roto i te tangata o te GFH375 i tīmatahia e GenFleet i Haina ki te wāhanga II, ā, ko ngā raraunga whai huatanga me te haumaru tuatahi o tēnei rangahau i tīpakohia ki roto i te whakaaturanga ā-waha tere i te Hui-ā-Tau a te American Society of Clinical Oncology (ASCO) 2025 e haere ake nei.
Ko ngā pūmua RAS, i roto i te āhua hohe e herea ana ki te GTP, i te āhua kore rānei e herea ana ki te GDP, he pana ngota rua e whakahaere ana i ngā urupare pūtau i roto i ngā ara tohu tae atu ki te RAS-RAF-MEK-ERK me te PI3K/AKT/mTOR. E toru ngā ira RAS e whakamārama ana mō ngā momo pūmua, arā, ko Kirsten Ras (KRAS), ko Harvey Ras (HRAS) me te Neuroblastoma Ras (NRAS), ā, ko KRAS te oncogene tino maha te whakarerekētanga i roto i te tangata. I roto i ngā whakarerekētanga KRAS, ko te G12D, G12V, me te G12C ngā ira matua e toru e tino maha te whakarerekētanga. Ko te whakarerekētanga KRAS G12D ka kitea noa i roto i te adenocarcinoma ductal pancreatic, te mate pukupuku colorectal, me te adenocarcinoma pūkahukahu.
He nui te ōrau o ngā tūroro e mau ana i te whakarerekētanga KRAS G12D kāore i te hītori momi hikareti, ā, kāore hoki i te pai te urupare ki ngā aukati PD-1. E whakaatu ana ngā aukati G12D whiriwhiri-mutunga i ngā painga ki ngā wāhanga nui o ngā tūroro PDAC e peia ana e te KRAS, nā te mea ko ngā whakarerekētanga KRAS G12D te huringa tinana e tino kitea ana i roto i ngā tūroro PDAC (tata ki te 40%), ā, e kīia ana he iti iho i te 10% te ōrau oranga mō te 5 tau.
He aukati KRAS G12D (ON/OFF) ngota iti kaha-waha, kaha, tino whiriwhiri hoki a GFH375, i hangaia hei arotahi ki te whakawhitiwhiti GTP/GDP, ā, ka whakararu i te whakahohenga o ngā ara o raro, ā, ka ārai pai i te tipu o ngā pūtau pukupuku. I whakaatuhia e ngā rangahau haumanu-mua te aukati e whakawhirinaki ana ki te horopeta i roto i ngā tauira e mau ana i te whakarerekētanga KRAS G12D; i whakaatuhia hoki e GFH375 te iti o te mōrearea ki waho o te ūnga i roto i ngā whakamātautau tīpakonga kinase me te ūnga haumaru.
I tēnei wā, he maha tonu ngā whakamātautau haumanu o ngā hangarau hou hei ārai i te matepukupuku i Haina e rapu ana i ngā tūroro. Mēnā kei te hiahia koe ki te kōrero mō ngā rongoā me ngā hangarau hou, ka taea e koe te whakapā atu ki te Tari Ao o te Hōhipera Oncology Rohe Tonga o Beijing.
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Wā tuku: Paenga-whāwhā-25-2025