I te 9 o Pēpuere, 2026, i panuitia e te paetukutuku mana o te Center for Drug Evaluation (CDE) o te National Medical Products Administration (NMPA) kua whakamaheretia kia whakawhiwhia ki te Breakthrough Therapy Designation te ZL-1310 mō te werohanga, he hononga antibody-drug (ADC) hou e arotahi ana ki te DLL3.
Hei mema mō te Peking University Cancer Hospital Medical Consortium me te hōhipera tuarua hou o Beijing e motuhake ana ki te mate pukupuku, ka whakamahia e te Tari Ao o te Beijing South Region Oncology Hospital he tūāpapa pakari mō te tātaritanga me te maimoatanga maha-mātauranga hei whakauru tere i aua maimoatanga matua o te ao ki roto i ngā mahere maimoatanga o ngā tūroro o te ao. Mena kei te pāngia koe, e tō whanaunga rānei, e ngā wero o te maimoatanga raina tuarua, o muri rānei mō te mate pukupuku pūkahukahu iti, tēnā pānuihia ngā raraunga i raro nei, ka whakapā mai ki a mātou tonu.
Whakapā atu ki te Tari Ao o te Hōhipera Matepukupuku o te Rohe Tonga o Beijing inaianei:
- Waea: 400-880-3716
- Tau WeChat: 17801183037
- Email ①: 100085_010@163.com
- Email ②: myimmnet@163.com
**Raraunga Mārō: Tae atu ki te 86% te Whai Huatanga i roto i ngā Tūroro me ngā Metastases Roro**
I te Hui-ā-Tau a te American Society of Clinical Oncology (ASCO) i te tau 2025, i whakaaturia ngā raraunga rangahau haumanu ā-ao mō te wahanga 1a/1b mō ZL-1310.
Mō ngā tūroro kua rongoatia i mua (maimoatanga raina tuarua):
- I eke te reiti urupare whāinga kāore anō kia whakaūtia (uORR) ki te 67%, me te reiti whakahaere mate (DCR) ki te 97%.
- I roto i te rōpū horopeta koiora tino pai (1.6 mg/kg): I piki ake te tere urupare whāinga (ORR) ki te 79%, me te tere whakahaere mate (DCR) o te 100%.
- Ko te tikanga tēnei: Tata ki ngā tūroro 10 katoa i whiwhi i tēnei horopeta i eke ki te mana whakahaere o te pukupuku, ā, tata ki te 8 ngā tūroro i pāngia e te whakahekenga nui o te pukupuku.
Mō ngā tūroro tino uaua e pāngia ana e te mate pukupuku roro:
- Ngā tūroro kua horapa te mate ki te roro i te tīmatanga: Ko te reiti urupare whāinga (ORR) he 68%.
- Ngā tūroro kāore anō kia whiwhi i te radiotherapy angaanga: Ko te reiti urupare whāinga (ORR) i eke ki te 86%!
He mea hou tēnei raraunga. He uaua ki ngā rongoā chemotherapy tuku iho te uru ki te arai toto-roro, engari he kaha te mahi ārai-puku a ZL-1310 i roto i te angaanga. Mō ngā tūroro o te ao e āwangawanga ana mō ngā pānga taha o te radiotherapy roro katoa, he tumanako nui tēnei ki te "ārai i te radiation roro."
**Kōtaha Haumaru:** I roto i te rōpū horopeta <2.0 mg/kg, ko te auau o ngā pānga kino e pā ana ki te maimoatanga (TRAE) o te taumata 3, neke atu rānei, he 6% noa iho, kāore he mate pūkahukahu interstitial e pā ana ki te maimoatanga (ILD) me ngā pānga whakamutu maimoatanga i pūrongohia.
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**III. He aha i whiriwhiri ai i te Tari Ao o te Hōhipera Matepukupuku o te Rohe Tonga o Beijing?**
Mō ngā tūroro o tāwāhi, ko te urunga atu ki ngā maimoatanga hou ehara i te mea ko "te wātea o te rongoā anake," engari he tukanga pūnaha anō hoki e uru ana ki "ko wai ka taea te whakamahi, me pēhea te whakamahi, me wai hoki e whakahaere ana i ngā pānga taha."
Mā te Tari Ao o te Hōhipera Matepukupuku o te Rohe Tonga o Beijing ka whakaratohia he aromatawai tirohanga whakamua me te whakahaere huringa katoa mō ngā maimoatanga hou pēnei i te ZL-1310 mō ngā tūroro e tika ana. Ahakoa nō Āhia ki te Tonga-mā-rāwhiti koe, nō te Waenganui Rawhiti, nō Ūropi, nō Amerika rānei, he tukanga ratonga hauora ā-ao kua whakapumautia pai tā mātou.
Kei a mātou ngā ratonga whānui mai i ngā kōrerorero i mua i te hōhipera, te whakamāori reo maha, ngā reta visa hauora, tae atu ki ngā mahi whakaora. Mā te piripono ki te kaupapa here "kotahi te tākuta, kotahi te tūroro, kotahi te rūma" ka tino whakautehia tō tūmataitinga me tō mana, ahakoa kei te whenua kē koe.
I tēnei wā, kua whakawhiwhia a ZL-1310 ki te tohu Orphan Drug Designation me te Fast Track Designation e te US FDA. Mā tōna whakaurunga kua whakamaheretia ki roto i te Breakthrough Therapy Designation o Haina ka tere ake te urunga atu ki Haina.
Kaua e tukua ngā arai reo, ngā āputa kōrero, ngā tikanga uaua rānei kia kore ai koe e uru atu ki ngā maimoatanga matatau. Kua whakatūria e te Tari Ao o te Hōhipera Oncology Rohe Tonga o Beijing he hongere matomato mō ngā tūroro o tāwāhi.
Waea mai, whakapā mai rānei mā WeChat, īmēra rānei, hei whakapuaki mai i tō āhuatanga. Ka whakaratohia e ā mātou kaitohutohu hauora he aromatawai tuatahi i roto i ngā haora 24.
- Waea (kōrerorero 24-hāora): 400-880-3716
- WeChat (whakawhitiwhiti kōrero inamata): 17801183037 (e tautoko ana i te reo Pākehā me te reo Hainamana)
- Īmēra (mō ngā tuhinga hauora):
- 100085_010@163.com
- myimmnet@163.com
Wā tuku: 12-Pepuere-2026