Pūrongo Take mō te Urupare Katoa mō te Wā Roa i roto i te Mate Pukupuku Hepatocellular ki ngā Pūtau T GPC3 CAR (CT011)

He hua pūtau-T CAR GPC3 autologous a CT011 hei rongoā i te mate pukupuku hepatocellular (HCC). I whiwhi a CT011 i te whakaaetanga IND mai i te NMPA i te tau 2019 hei rongoā i ngā tūroro he pukupuku totoka GPC3-pai, koinei te whakaaetanga IND tuatahi a Haina mō te rongoā pūtau-T CAR ki ngā pukupuku totoka.

18 o Ākuhata, 2022, kei te pānuitia e CARsgen Therapeutics kua whakaputaina he pūrongo take, ko te taitara "Rong Term Complete Response of Advanced Hepatocellular Carcinoma to Glypican-3 Specific Chimeric Antigen Receptor T-Cells me te Sorafenib, He pūrongo take", i roto i te Frontiers in Immunology.

I whakaatuhia i roto i te kēhi he tūroro tāne Āhia 60-tau te pakeke me te mate pukupuku ate B (HBV) e pā ana ki te HCC i pokangahia i te marama o Mei 2018. I te marama o Ākuhata 2018, ka hoki mai te mate pukupuku ate me te metastasis pūkahukahu i muri i te pokanga, kātahi ka whiwhi ia i te transarterial chemoembolization (TACE) hei rongoā i ngā whara ate me te wawaotanga ablation hei rongoā i ngā metastases pūkahukahu. E rua marama i muri mai, ka ahu whakamua ia, ā, ka whakaurua ki te whakamātautau haumanu. Whai muri i te whakaurunga, ka whiwhi te tūroro i te leukapheresis mō te hanga pūtau-T CAR-GPC3. E whitu ngā rā i muri i te leukapheresis, ka tīmata te tūroro ki te whiwhi i te 400 mg o te sorafenib e rua ngā wā i te rā. I whiwhi te tūroro i te 4 huringa o te maimoatanga pūtau-T CAR-GPC3 (CT011) ā, i wehea ia huringa kia rua ngā werohanga. I mua i ia huringa o te maimoatanga CT011, i mahia te lymphodepletion. He 4×10 katoa⁹I whakauruhia ngā pūtau-T CAR-GPC3.

I pai te manawanui ki te whakakotahitanga o te rongoā CT011 me te sorafenib. I whiwhi tēnei tūroro i ngā urupare hapa (PR) mai i te marama tuatoru, ā, i tutuki te CR i te marama 12 i muri i te huringa tuatahi o te werohanga CT011. Kāore i piki haere te pukupuku mō te neke atu i te 36 marama, ā, i mau tonu te mana CR mō te neke atu i te 24 marama i muri i te werohanga tuatahi.

Ki tā mātou e mōhio nei, koinei te kēhi tuatahi i pūrongohia me te CR i muri i te whakakotahitanga o ngā pūtau CAR T me ngā aukati tyrosine kinase. I whakaatuhia e te putanga haumanu ko te whakakotahitanga o te pūtau CAR T GPC3 me te Sorafenib he huarahi hou pea hei whai hua mō ngā tūroro HCC matatau GPC3+.

I tēnei wā, he maha atu ngā whakamātautau haumanu CAR-T i Haina, ā, kei te rapu tūroro rātou. Mō te kōrerorero mō ngā rongoā me ngā hangarau hou, ka taea e koe te whakapā atu ki te Tari Ao o te Hōhipera Oncology Rohe Tonga o Beijing.

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