I roto i ngā wiki e 4 i muri i te whiwhinga o te rongoā TIL hou, i ngaro katoa te pukupuku i roto i tētahi tūroro mate pukupuku roro kua tata mate, ā, kua hoki anō te mate i muri i ngā maimoatanga CAR-T 17. Ā, neke atu i te 20 marama ia e kore rawa ana pukupuku e puta.
Mō ngā pātai e pā ana ki ngā maimoatanga mate pukupuku hou me ngā whakamātautau haumanu:
Waea: 4008803716 | WeChat: 17801183037| Email ：100085_010@163.com
I tāpaetia he mate glioblastoma o te roro maui o tētahi tūroro tāne 56-tau te pakeke (IDH wild-type, WHO Grade 4, EGFR amplification)—tētahi o ngā momo glioma roro tino kino, tino uaua hoki ki te rongoā.
I muri i te tangohanga o te pukupuku i te 5 o Hānuere, 2023, i te tuatahi i whiwhi ia i te maimoatanga paerewa, engari i hoki anō tōna āhua i muri i te wā poto o te pumau. I muri mai, i whiwhi ia i te katoa o ngā maimoatanga CAR-T 17 e aro ana ki ngā momo antigens e rua, engari i haere tonu tana mate ki te whanake.
I roto i te pouri, i whakauru ia ki tētahi whakamātautau haumanu mō tētahi rongoā TIL hou. He mīharo ngā hua: e 4 wiki noa iho i muri i te werohanga pūtau TIL, i whakaatuhia e ngā whakamātautau whakaahua kua tino tangohia te pukupuku i roto i tōna roro, ā, kua tino tauhohe, ā, kua noho kore pukupuku ia mō ngā marama neke atu i te 20.
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Te Whawhai mō te Ora i roto i te Āhuatanga Pōuri
E mōhiotia ana a Glioblastoma ko te "kaikōhuru nama tuatahi o roto i te angaanga." Ko te wā o te tautuhi mate e rite ana ki te tīmatanga o te tatau whakamuri o te ora.
I muri i te tātaritanga o Mr. W, i tangohia tuatahitia ia e te pukupuku roro mōrearea nui, ā, i muri mai ka whakamahia te chemotherapy temozolomide me te radiotherapy. Heoi, kāore i taea te whakahaere i tōna āhua.
I muri mai, i whakamātau ia i ngā maimoatanga CAR-T e rua e aro ana ki ngā momo antigens rerekē, ā, neke atu i te 10 ngā werohanga ā-roto o te pukupuku i whiwhihia i te wā kotahi, engari kāore i taea te aukati i te whanaketanga o te pukupuku.
He iti noa te whai huatanga o ngā maimoatanga tuku iho ki te ārai i te glioma roro kua pāngia. Ahakoa ngā mahere maimoatanga whakakotahi e uru ana ki te pokanga, te radiotherapy, me te chemotherapy, ko te roanga oranga toharite mō ngā tūroro he 14.6 marama noa iho.
I te aroaro o tēnei āhuatanga kore tumanako, i tino pouri a Mr. W me tōna whānau tae noa ki tō rātou rongonga mō te whakamātautau haumanu TIL therapy.
Te Whakaora TIL
Ko te whakaora TIL, e kiia ana ko te whakaora Tumor-Infiltrating Lymphocyte, he rongoā ārai mate pūtau auaha.
Ka tīmata tēnei rongoā mā te whakamahi i te kiko hou o te pukupuku o te tūroro hei rauemi mata. Whai muri i te wehenga, te whakarerekētanga, me te whakawhānui i roto i te vitro, ka whakahokia ngā pūtau ki roto i te tūroro, ka tutuki ai te maimoatanga tika e "pakanga ana i te pukupuku ki a ia anō."
He rerekē ki te rongoā CAR-T tuku iho, kāore e hiahiatia he werohanga lymphodepletion, he werohanga IL-2 rānei mō te rongoā GC101 TIL, ā, ka nui ake te haumaru me te ngāwari o te rongoā.
I whakawhanakehia e Juncell Therapeutics, ko te rongoā GC101 TIL te rongoā TIL tūturu tuatahi o te ao e kore e hiahiatia he lymphodepletion, he werohanga IL-2 rānei, mā te whakamahi i tana tūāpapa whakawhānui pūtau DeepTIL® i whakawhanakehia e ia anō.
E whakaatu ana ngā raraunga haumanu o nāianei he nui ake te tere urupare ā-taurangi a GC101 i te 35% ki ngā momo pukupuku totoka kua whanake haere. He maha ngā tūroro kua tutuki te whakakorenga katoa o te pukupuku me te urupare katoa, ā, neke atu i te 3 tau te roa o te oranga kore pukupuku.
Te Tukanga Maimoatanga
I te mutunga o te tau 2023, i angitu te whakaurunga a Mr. W ki te whakamātautau haumanu whakaora GC101 TIL.
I whakamahia e te tīma hauora ngā pūtau TIL i whakatipuria mai i tana tauira pokanga i riro mai i te tau i mua atu, i tiakina kia tae rā anō ki te wā e hiahiatia ana.
I angitu te rōpū maimoatanga ki te whakawhānui i ngā pūtau ki te tapeke o ngā pūtau TIL e 2.95 × 10^10, ko ngā pūtau-T te 99.92% o te taupori, ko te nuinga he pūtau-T CD8⁺ (97.85%).
Whai muri i te whakatōnga i mua i te whakatōnga, i whiwhi a Mr. W i te werohanga pūtau TIL i te 12 o Hakihea, 2023.
I te wā e werohia ana, kāore a Mr. W i pāngia e ngā tauhohenga kino, engari he kirika ngawari noa iho i tere te memeha. Ki te whakatauritea ki ngā rongoā TIL tuku iho, i whakaatuhia e tēnei putanga whakarerekētia he haumaru ake.
He Hurihanga Whakamiharo
E whā wiki noa iho i muri i te werohanga pūtau TIL, i whakaatuhia e ngā whakamātautau whakaahua i te 8 o Hānuere, 2024, kua tino tangohia te pukupuku i roto i te roro o Mr. W.
Heoi anō, tae noa ki Oketopa 2025, kua ora tonu te tūroro i te korenga o te pukupuku mō te neke atu i te 1.8 tau (i tatauhia i te wā o te panuitanga pāpāho, neke atu i te 20 marama tēnei), ā, kua hoki anō ki te oranga noa.
Kua whakatūria e tēnei kēhi he rēkoata oranga hou mō te glioblastoma e hokihoki mai ana, ā, e whakarato ana i ngā taunakitanga haumanu nui mō te rautaki maimoatanga o te "kohikohi kiko wawe, te whakauru anō o te TIL ina hoki mai anō."
Ka whakaatuhia tēnei whakatutukitanga whakamiharo i roto i tētahi pānui i te Hui-ā-Tau 40 o te Rōpū mō te Whakaora Matepukupuku Matepukupuku, ka tū mai i te 7-9 o Noema, 2025, hei whakaatu ki ngā tohunga o te ahumahi o te ao.
Ngā Tūmanako ā-Mārama
Kua whakaatuhia e te rongoā TIL te kaha ehara i te mea ki te maimoatanga i te glioma roro anake, engari he whai huatanga whakamiharo hoki ki ētahi atu pukupuku totoka pēnei i te melanoma matatau me te mate pukupuku pūkahukahu ehara i te pūtau iti.
I te marama o Pēpuere 2024, i whakaaetia e te FDA i te United States te rongoā pūtau TIL tuatahi o te ao, a Lifileucel, mō te rongoā i ngā tūroro he melanoma kua pāngia e te mate pukupuku nui kua whiwhi i te rongoā aukati PD-1 i mua.
I taua wā anō, kei te kaha te whakatairanga a Haina i ngā rangahau haumanu mō te rongoā TIL. Kua whakaaetia e te Center for Drug Aromatawai o te National Medical Products Administration te whakamātautau haumanu matua mō te rēhitatanga Wāhanga II mō te werohanga GC101 TIL a Juncell Therapeutics e aro ana ki te melanoma matatau.
I tua atu, i te 14 o Oketopa, 2024, i tīmata mana te whakamātautau rēhitatanga rongoā pūtau TIL tuatahi a Haina mō te mate pukupuku pūkahukahu, i hangaia mō te rongoā i te mate pukupuku pūkahukahu ehara i te pūtau iti kua whanake.
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I tēnei wā, he maha tonu ngā whakamātautau haumanu mō ngā rongoā me ngā hangarau hou hei ārai i te matepukupuku i Haina e rapu ana i ngā tūroro.
Ka whakaratohia e te Tari Ao o te Hōhipera Matepukupuku o te Rohe Tonga o Beijing he ratonga kōrero mō ngā rongoā me ngā hangarau hou.
Tau Waea: 4008803716
WeChat ID: 17801183037
Email ①: 100085_010@163.com
Email ②: myimmnet@163.com
Wā tuku: Whiringa-ā-rangi 20-2025