Nō nā tata nei, i tutuki i te rangahau CLINCH Wāhanga I/II a Antengene mō te ATG-022 (CLDN18.2 antibody-drug conjugate), he tūroro kaumātua kua pāngia e te mate pukupuku puku kua whanake haere, ā, kua ahu whakamua i runga i ngā momo rongoā chemotherapy, immunotherapy me te therapy arotahi ahakoa te whānui o ngā metastases i roto i te pūtau, he urupare katoa (CR) i muri i te ATG-022 monotherapy. I whakaūtia te korenga o te pukupuku o te tūroro e te PET/CT i te marama o Mei 2025.
I tēnei wā, he maha tonu ngā whakamātautau haumanu o ngā hangarau hou hei ārai i te matepukupuku i Haina e rapu ana i ngā tūroro. Mēnā kei te hiahia koe ki te kōrero mō ngā rongoā me ngā hangarau hou, ka taea e koe te whakapā atu ki te Tari Ao o te Hōhipera Oncology Rohe Tonga o Beijing.
Tau Waea：4008803716
WeChat ID: 17801183037
Email：myimmnet@163.com
Ko te ATG-022 he CLDN18.2 ADC i kitea, ā, i whakawhanakehia hoki e Antengene i roto i te whare. I te huihuinga ASCO GI 2025 i te tīmatanga o tēnei tau, i whakaatu a Antengene i ngā raraunga haumanu hou mō te ATG-022. I roto i ngā tūroro he whakapuakanga CLDN18.2 waenga-ki-teitei (IHC 2+ ≥ 20%), ko te reiti urupare whāinga (ORR) he 42.9%, ā, ko te reiti whakahaere mate (DCR) he 95.2%. I roto i ngā tūroro he iti te whakapuakanga CLDN18.2 (IHC 2+ < 20%), ko te ORR he 30.0%, ā, ko te DCR he 50.0%. E whakaatu ana ēnei raraunga ka tukuna e te ATG-022 he whai huatanga haumanu me te kōtaha haumaru pai puta noa i te whānuitanga o ngā taumata whakapuakanga CLDN18.2, tae atu ki te whakapuakanga teitei, iti, tae atu ki te whakapuakanga tino-iti. Ko tōna kaha ārai-puku whānui e kī ana ka taea e ATG-022 te tuku i ngā painga rongoā ki tētahi taupori tūroro whānui atu i ērā atu rongoā e arohia ana ki te CLDN18.2. I tēnei wā, kei te haere tonu te rangahau whakawhānui horopeta Wāhanga II o ATG-022 i te tuawhenua o Haina me Ahitereiria.
He tino whakatenatena tēnei whakatutukitanga o te CR i roto i tēnei tūroro matepukupuku puku kaumātua, e whakaatu ana i te kaha rongoā o te ATG-022 hei rongoā ADC hou. He mea nui, ehara i te mea koinei anake te CR i kitea i roto i te rangahau e haere tonu ana. Tae noa ki tēnei wā, e toru ngā kēhi CR kua kitea, tae atu ki ngā tūroro mai i te tuawhenua o Haina me Ahitereiria. Kei te tumanako a Antengene ki te whakaatu i ngā raraunga hou mai i te rangahau ATG-022 ki te Huihuinga ESMO e tū mai nei i te Oketopa 2025.
I tēnei wā, he maha tonu ngā whakamātautau haumanu o ngā hangarau hou hei ārai i te matepukupuku i Haina e rapu ana i ngā tūroro. Mēnā kei te hiahia koe ki te kōrero mō ngā rongoā me ngā hangarau hou, ka taea e koe te whakapā atu ki te Tari Ao o te Hōhipera Oncology Rohe Tonga o Beijing.
Tau Waea：4008803716
WeChat ID: 17801183037
Email：myimmnet@163.com
Wā tuku: 21 o Ākuhata-2025